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Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Goel P, Jumpertz T, Mikles DC, Tichá A, Nguyen MTN, Verhelst S, Hubalek M, Johnson DC, Bachovchin DA, Ogorek I, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S. Goel P, et al. Among authors: hubalek m. Biochemistry. 2017 Dec 26;56(51):6713-6725. doi: 10.1021/acs.biochem.7b01066. Epub 2017 Dec 12. Biochemistry. 2017. PMID: 29185711 Free PMC article.
Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3.
Heine V, Hovorková M, Vlachová M, Filipová M, Bumba L, Janoušková O, Hubálek M, Cvačka J, Petrásková L, Pelantová H, Křen V, Elling L, Bojarová P. Heine V, et al. Among authors: hubalek m. Eur J Med Chem. 2021 Aug 5;220:113500. doi: 10.1016/j.ejmech.2021.113500. Epub 2021 Apr 27. Eur J Med Chem. 2021. PMID: 33962190
A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.
Chrudinová M, Žáková L, Marek A, Socha O, Buděšínský M, Hubálek M, Pícha J, Macháčková K, Jiráček J, Selicharová I. Chrudinová M, et al. Among authors: hubalek m. J Biol Chem. 2018 Oct 26;293(43):16818-16829. doi: 10.1074/jbc.RA118.004852. Epub 2018 Sep 13. J Biol Chem. 2018. PMID: 30213860 Free PMC article.
Kinetic Target-Guided Synthesis of Small-Molecule G-Quadruplex Stabilizers.
Pomeislová A, Vrzal L, Kozák J, Dobiaš J, Hubálek M, Dvořáková H, Reyes-Gutiérrez PE, Teplý F, Veverka V. Pomeislová A, et al. Among authors: hubalek m. ChemistryOpen. 2020 Dec 3;9(12):1236-1250. doi: 10.1002/open.202000261. eCollection 2020 Dec. ChemistryOpen. 2020. PMID: 33304739 Free PMC article.
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.
Leontovyč A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvořák J, Horn M. Leontovyč A, et al. Among authors: hubalek m. PLoS Negl Trop Dis. 2018 Apr 20;12(4):e0006446. doi: 10.1371/journal.pntd.0006446. eCollection 2018 Apr. PLoS Negl Trop Dis. 2018. PMID: 29677188 Free PMC article.
142 results