Irani S - Search Results

1

Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism.

Irani S, Naowarojna N, Tang Y, Kathuria KR, Wang S, Dhembi A, Lee N, Yan W, Lyu H, Costello CE, Liu P, Zhang YJ. Irani S, et al. Cell Chem Biol. 2018 May 17;25(5):519-529.e4. doi: 10.1016/j.chembiol.2018.02.002. Epub 2018 Mar 1. Cell Chem Biol. 2018. PMID: 29503207 Free PMC article.

2

Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.

Li W, Irani S, Crutchfield A, Hodge K, Matthews W, Patel P, Zhang YJ, Stone E. Li W, et al. Among authors: irani s. Biochemistry. 2016 Feb 16;55(6):960-9. doi: 10.1021/acs.biochem.5b01157. Epub 2016 Feb 2. Biochemistry. 2016. PMID: 26780688 Free PMC article.

3

Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase.

Irani S, Yogesha SD, Mayfield J, Zhang M, Zhang Y, Matthews WL, Nie G, Prescott NA, Zhang YJ. Irani S, et al. Sci Signal. 2016 Mar 1;9(417):ra24. doi: 10.1126/scisignal.aad4805. Sci Signal. 2016. PMID: 26933063 Free PMC article.

4

Mapping the Phosphorylation Pattern of Drosophila melanogaster RNA Polymerase II Carboxyl-Terminal Domain Using Ultraviolet Photodissociation Mass Spectrometry.

Mayfield JE, Robinson MR, Cotham VC, Irani S, Matthews WL, Ram A, Gilmour DS, Cannon JR, Zhang YJ, Brodbelt JS. Mayfield JE, et al. Among authors: irani s. ACS Chem Biol. 2017 Jan 20;12(1):153-162. doi: 10.1021/acschembio.6b00729. Epub 2016 Dec 1. ACS Chem Biol. 2017. PMID: 28103682 Free PMC article.

5

Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity.

Burkholder NT, Medellin B, Irani S, Matthews W, Showalter SA, Zhang YJ. Burkholder NT, et al. Among authors: irani s. Methods Enzymol. 2018;607:269-297. doi: 10.1016/bs.mie.2018.04.020. Epub 2018 Jun 23. Methods Enzymol. 2018. PMID: 30149861 Free PMC article.

6

Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).

Burkholder NT, Mayfield JE, Yu X, Irani S, Arce DK, Jiang F, Matthews WL, Xue Y, Zhang YJ. Burkholder NT, et al. Among authors: irani s. J Biol Chem. 2018 Oct 26;293(43):16851-16861. doi: 10.1074/jbc.RA118.004722. Epub 2018 Sep 14. J Biol Chem. 2018. PMID: 30217818 Free PMC article.

7

Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.

Irani S, Sipe SN, Yang W, Burkholder NT, Lin B, Sim K, Matthews WL, Brodbelt JS, Zhang Y. Irani S, et al. J Biol Chem. 2019 May 24;294(21):8592-8605. doi: 10.1074/jbc.RA119.007697. Epub 2019 Apr 10. J Biol Chem. 2019. PMID: 30971428 Free PMC article.

8

Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb.

Mayfield JE, Irani S, Escobar EE, Zhang Z, Burkholder NT, Robinson MR, Mehaffey MR, Sipe SN, Yang W, Prescott NA, Kathuria KR, Liu Z, Brodbelt JS, Zhang Y. Mayfield JE, et al. Among authors: irani s. Elife. 2019 Aug 6;8:e48725. doi: 10.7554/eLife.48725. Elife. 2019. PMID: 31385803 Free PMC article.

9

Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering To Modulate Its Substrate Selectivity.

Naowarojna N, Irani S, Hu W, Cheng R, Zhang L, Li X, Chen J, Zhang YJ, Liu P. Naowarojna N, et al. Among authors: irani s. ACS Catal. 2019 Aug 2;9(8):6955-6961. doi: 10.1021/acscatal.9b02054. Epub 2019 Jul 2. ACS Catal. 2019. PMID: 32257583 Free PMC article.

10

Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.

Lu WC, Saha A, Yan W, Garrison K, Lamb C, Pandey R, Irani S, Lodi A, Lu X, Tiziani S, Zhang YJ, Georgiou G, DiGiovanni J, Stone E. Lu WC, et al. Among authors: irani s. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):13000-13011. doi: 10.1073/pnas.1917362117. Epub 2020 May 20. Proc Natl Acad Sci U S A. 2020. PMID: 32434918 Free PMC article.

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