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Page 1
Precise Cas9 targeting enables genomic mutation prevention.
Chavez A, Pruitt BW, Tuttle M, Shapiro RS, Cecchi RJ, Winston J, Turczyk BM, Tung M, Collins JJ, Church GM. Chavez A, et al. Among authors: pruitt bw. Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3669-3673. doi: 10.1073/pnas.1718148115. Epub 2018 Mar 19. Proc Natl Acad Sci U S A. 2018. PMID: 29555762 Free PMC article.
Cas9 gRNA engineering for genome editing, activation and repression.
Kiani S, Chavez A, Tuttle M, Hall RN, Chari R, Ter-Ovanesyan D, Qian J, Pruitt BW, Beal J, Vora S, Buchthal J, Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R, Church G. Kiani S, et al. Among authors: pruitt bw. Nat Methods. 2015 Nov;12(11):1051-4. doi: 10.1038/nmeth.3580. Epub 2015 Sep 7. Nat Methods. 2015. PMID: 26344044 Free PMC article.
Highly efficient Cas9-mediated transcriptional programming.
Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM. Chavez A, et al. Among authors: pruitt bw. Nat Methods. 2015 Apr;12(4):326-8. doi: 10.1038/nmeth.3312. Epub 2015 Mar 2. Nat Methods. 2015. PMID: 25730490 Free PMC article.
Comparison of Cas9 activators in multiple species.
Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJK, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G. Chavez A, et al. Among authors: pruitt bw. Nat Methods. 2016 Jul;13(7):563-567. doi: 10.1038/nmeth.3871. Epub 2016 May 23. Nat Methods. 2016. PMID: 27214048 Free PMC article.
Design, synthesis, and testing toward a 57-codon genome.
Ostrov N, Landon M, Guell M, Kuznetsov G, Teramoto J, Cervantes N, Zhou M, Singh K, Napolitano MG, Moosburner M, Shrock E, Pruitt BW, Conway N, Goodman DB, Gardner CL, Tyree G, Gonzales A, Wanner BL, Norville JE, Lajoie MJ, Church GM. Ostrov N, et al. Among authors: pruitt bw. Science. 2016 Aug 19;353(6301):819-22. doi: 10.1126/science.aaf3639. Science. 2016. PMID: 27540174