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CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy.
Sardi SP, Clarke J, Kinnecom C, Tamsett TJ, Li L, Stanek LM, Passini MA, Grabowski GA, Schlossmacher MG, Sidman RL, Cheng SH, Shihabuddin LS. Sardi SP, et al. Among authors: stanek lm. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12101-6. doi: 10.1073/pnas.1108197108. Epub 2011 Jul 5. Proc Natl Acad Sci U S A. 2011. PMID: 21730160 Free PMC article.
Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice.
Pouladi MA, Stanek LM, Xie Y, Franciosi S, Southwell AL, Deng Y, Butland S, Zhang W, Cheng SH, Shihabuddin LS, Hayden MR. Pouladi MA, et al. Among authors: stanek lm. Hum Mol Genet. 2012 May 15;21(10):2219-32. doi: 10.1093/hmg/dds037. Epub 2012 Feb 9. Hum Mol Genet. 2012. PMID: 22328089
Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease.
Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Samaranch L, Pivirotto P, Bringas J, O'Riordan C, Mastis B, San Sebastian W, Forsayeth J, Cheng SH, Bankiewicz KS, Shihabuddin LS. Hadaczek P, et al. Mol Ther Methods Clin Dev. 2016 Jun 29;3:16037. doi: 10.1038/mtm.2016.37. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 27408903 Free PMC article.
Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS.
Naidoo J, Stanek LM, Ohno K, Trewman S, Samaranch L, Hadaczek P, O'Riordan C, Sullivan J, San Sebastian W, Bringas JR, Snieckus C, Mahmoodi A, Mahmoodi A, Forsayeth J, Bankiewicz KS, Shihabuddin LS. Naidoo J, et al. Among authors: stanek lm. Mol Ther. 2018 Oct 3;26(10):2418-2430. doi: 10.1016/j.ymthe.2018.07.008. Epub 2018 Jul 12. Mol Ther. 2018. PMID: 30057240 Free PMC article.
19 results