Guo J - Search Results

1

Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors.

Guo J, Zhao F, Yin W, Zhu M, Hao C, Pang Y, Wu T, Wang J, Zhao D, Li H, Cheng M. Guo J, et al. Eur J Med Chem. 2018 Jul 15;155:197-209. doi: 10.1016/j.ejmech.2018.05.051. Epub 2018 Jun 1. Eur J Med Chem. 2018. PMID: 29886323

2

Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors.

Song S, Li X, Guo J, Hao C, Feng Y, Guo B, Liu T, Zhang Q, Zhang Z, Li R, Wang J, Lin B, Li F, Zhao D, Cheng M. Song S, et al. Among authors: guo b, guo j. Org Biomol Chem. 2015 Mar 28;13(12):3803-18. doi: 10.1039/c5ob00037h. Org Biomol Chem. 2015. PMID: 25705811

3

Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion.

Hao C, Li X, Song S, Guo B, Guo J, Zhang J, Zhang Q, Huang W, Wang J, Lin B, Cheng M, Li F, Zhao D. Hao C, et al. Among authors: guo b, guo j. Org Biomol Chem. 2016 Aug 10;14(32):7676-90. doi: 10.1039/c6ob01072e. Org Biomol Chem. 2016. PMID: 27454186

4

Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy.

Hao C, Huang W, Li X, Guo J, Chen M, Yan Z, Wang K, Jiang X, Song S, Wang J, Zhao D, Li F, Cheng M. Hao C, et al. Among authors: guo j. Eur J Med Chem. 2017 May 5;131:1-13. doi: 10.1016/j.ejmech.2017.02.063. Epub 2017 Mar 8. Eur J Med Chem. 2017. PMID: 28284095

5

Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study.

Guo J, Zhu M, Wu T, Hao C, Wang K, Yan Z, Huang W, Wang J, Zhao D, Cheng M. Guo J, et al. Bioorg Med Chem. 2017 Jul 1;25(13):3500-3511. doi: 10.1016/j.bmc.2017.04.047. Epub 2017 May 3. Bioorg Med Chem. 2017. PMID: 28502459

6

Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.

Hao C, Zhao F, Song H, Guo J, Li X, Jiang X, Huan R, Song S, Zhang Q, Wang R, Wang K, Pang Y, Liu T, Lu T, Huang W, Wang J, Lin B, He Z, Li H, Li F, Zhao D, Cheng M. Hao C, et al. Among authors: guo j. J Med Chem. 2018 Jan 11;61(1):265-285. doi: 10.1021/acs.jmedchem.7b01342. Epub 2017 Dec 30. J Med Chem. 2018. PMID: 29190083

7

Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage.

Dai H, Ge S, Guo J, Chen S, Huang M, Yang J, Sun S, Ling Y, Shi Y. Dai H, et al. Among authors: guo j. Eur J Med Chem. 2018 Jan 1;143:1066-1076. doi: 10.1016/j.ejmech.2017.11.098. Epub 2017 Dec 5. Eur J Med Chem. 2018. PMID: 29232583

8

Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells.

Ling Y, Guo J, Yang Q, Zhu P, Miao J, Gao W, Peng Y, Yang J, Xu K, Xiong B, Liu G, Tao J, Luo L, Zhu Q, Zhang Y. Ling Y, et al. Among authors: guo j. Eur J Med Chem. 2018 Jan 20;144:398-409. doi: 10.1016/j.ejmech.2017.12.061. Epub 2017 Dec 20. Eur J Med Chem. 2018. PMID: 29288941

9

Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity.

Wu T, Pang Y, Guo J, Yin W, Zhu M, Hao C, Wang K, Wang J, Zhao D, Cheng M. Wu T, et al. Among authors: guo j. Molecules. 2018 Feb 14;23(2):417. doi: 10.3390/molecules23020417. Molecules. 2018. PMID: 29443911 Free PMC article.

10

Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities.

Ling Y, Yang QX, Teng YN, Chen S, Gao WJ, Guo J, Hsu PL, Liu Y, Morris-Natschke SL, Hung CC, Lee KH. Ling Y, et al. Among authors: guo j. Eur J Med Chem. 2018 Jun 25;154:199-209. doi: 10.1016/j.ejmech.2018.05.025. Epub 2018 May 18. Eur J Med Chem. 2018. PMID: 29803003 Free PMC article.

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