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Principles for targeting RNA with drug-like small molecules.
Warner KD, Hajdin CE, Weeks KM. Warner KD, et al. Among authors: weeks km. Nat Rev Drug Discov. 2018 Aug;17(8):547-558. doi: 10.1038/nrd.2018.93. Epub 2018 Jul 6. Nat Rev Drug Discov. 2018. PMID: 29977051 Free PMC article. Review.
Architecture and secondary structure of an entire HIV-1 RNA genome.
Watts JM, Dang KK, Gorelick RJ, Leonard CW, Bess JW Jr, Swanstrom R, Burch CL, Weeks KM. Watts JM, et al. Among authors: weeks km. Nature. 2009 Aug 6;460(7256):711-6. doi: 10.1038/nature08237. Nature. 2009. PMID: 19661910 Free PMC article.
RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP).
Siegfried NA, Busan S, Rice GM, Nelson JA, Weeks KM. Siegfried NA, et al. Among authors: weeks km. Nat Methods. 2014 Sep;11(9):959-65. doi: 10.1038/nmeth.3029. Epub 2014 Jul 13. Nat Methods. 2014. PMID: 25028896 Free PMC article.
SHAPE-enabled fragment-based ligand discovery for RNA.
Zeller MJ, Favorov O, Li K, Nuthanakanti A, Hussein D, Michaud A, Lafontaine DA, Busan S, Serganov A, Aubé J, Weeks KM. Zeller MJ, et al. Among authors: weeks km. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2122660119. doi: 10.1073/pnas.2122660119. Epub 2022 May 13. Proc Natl Acad Sci U S A. 2022. PMID: 35561226 Free PMC article.
172 results