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SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes.
Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey EE, Cohen NA, Weiss SR. Li Y, et al. Among authors: truitt r. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2022643118. doi: 10.1073/pnas.2022643118. Proc Natl Acad Sci U S A. 2021. PMID: 33811184 Free PMC article.
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2.
Dittmar M, Lee JS, Whig K, Segrist E, Li M, Kamalia B, Castellana L, Ayyanathan K, Cardenas-Diaz FL, Morrisey EE, Truitt R, Yang W, Jurado K, Samby K, Ramage H, Schultz DC, Cherry S. Dittmar M, et al. Among authors: truitt r. Cell Rep. 2021 Apr 6;35(1):108959. doi: 10.1016/j.celrep.2021.108959. Epub 2021 Mar 23. Cell Rep. 2021. PMID: 33811811 Free PMC article.
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
Kee J, Thudium S, Renner DM, Glastad K, Palozola K, Zhang Z, Li Y, Lan Y, Cesare J, Poleshko A, Kiseleva AA, Truitt R, Cardenas-Diaz FL, Zhang X, Xie X, Kotton DN, Alysandratos KD, Epstein JA, Shi PY, Yang W, Morrisey E, Garcia BA, Berger SL, Weiss SR, Korb E. Kee J, et al. Among authors: truitt r. Nature. 2022 Oct;610(7931):381-388. doi: 10.1038/s41586-022-05282-z. Epub 2022 Oct 5. Nature. 2022. PMID: 36198800 Free PMC article.
SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.
Ramachandran K, Maity S, Muthukumar AR, Kandala S, Tomar D, Abd El-Aziz TM, Allen C, Sun Y, Venkatesan M, Madaris TR, Chiem K, Truitt R, Vishnu N, Aune G, Anderson A, Martinez-Sobrido L, Yang W, Stockand JD, Singh BB, Srikantan S, Reeves WB, Madesh M. Ramachandran K, et al. Among authors: truitt r. iScience. 2022 Jan 1;25(1):103722. doi: 10.1016/j.isci.2021.103722. eCollection 2022 Jan 21. iScience. 2022. PMID: 35005527 Free PMC article.
108 results