Keil S - Search Results

1

A novel dual glucagon-like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo-controlled first-in-human and first-in-patient trials.

Tillner J, Posch MG, Wagner F, Teichert L, Hijazi Y, Einig C, Keil S, Haack T, Wagner M, Bossart M, Larsen PJ. Tillner J, et al. Among authors: keil s. Diabetes Obes Metab. 2019 Jan;21(1):120-128. doi: 10.1111/dom.13494. Epub 2018 Sep 16. Diabetes Obes Metab. 2019. PMID: 30091218 Clinical Trial.

2

Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates.

Elvert R, Herling AW, Bossart M, Weiss T, Zhang B, Wenski P, Wandschneider J, Kleutsch S, Butty U, Kannt A, Wagner M, Haack T, Evers A, Dudda A, Lorenz M, Keil S, Larsen PJ. Elvert R, et al. Among authors: keil s. Diabetes Obes Metab. 2018 Aug;20(8):1836-1851. doi: 10.1111/dom.13212. Epub 2018 Jun 25. Diabetes Obes Metab. 2018. PMID: 29938884 Free PMC article.

3

Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys.

Elvert R, Bossart M, Herling AW, Weiss T, Zhang B, Kannt A, Wagner M, Haack T, Evers A, Dudda A, Keil S, Lorenz M, Lorenz K, Riz M, Hennerici W, Larsen PJ. Elvert R, et al. Among authors: keil s. Endocrinology. 2018 Aug 1;159(8):3105-3119. doi: 10.1210/en.2018-00399. Endocrinology. 2018. PMID: 29992313

4

Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.

Keil S, Matter H, Schönafinger K, Glien M, Mathieu M, Marquette JP, Michot N, Haag-Diergarten S, Urmann M, Wendler W. Keil S, et al. ChemMedChem. 2011 Apr 4;6(4):633-53. doi: 10.1002/cmdc.201100047. Epub 2011 Mar 11. ChemMedChem. 2011. PMID: 21400663

5

Discovery and pharmacological characterization of SAR707 as novel and selective small molecule inhibitor of stearoyl-CoA desaturase (SCD1).

Voss MD, Zoller G, Matter H, Herling AW, Biemer-Daub G, Pfenninger A, Haag-Diergarten S, Keil S, Kohlmann M, Schmidts HL. Voss MD, et al. Among authors: keil s. Eur J Pharmacol. 2013 May 5;707(1-3):140-6. doi: 10.1016/j.ejphar.2013.03.019. Epub 2013 Mar 22. Eur J Pharmacol. 2013. PMID: 23524088

6

Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.

Keil S, Müller M, Zoller G, Haschke G, Schroeter K, Glien M, Ruf S, Focken I, Herling AW, Schmoll D. Keil S, et al. J Med Chem. 2010 Dec 23;53(24):8679-87. doi: 10.1021/jm101179e. Epub 2010 Nov 17. J Med Chem. 2010. PMID: 21082864

7

Stimulation of fat oxidation, but no sustained reduction of hepatic lipids by prolonged pharmacological inhibition of acetyl CoA carboxylase.

Glien M, Haschke G, Schroeter K, Pfenninger A, Zoller G, Keil S, Müller M, Herling AW, Schmoll D. Glien M, et al. Among authors: keil s. Horm Metab Res. 2011 Aug;43(9):601-6. doi: 10.1055/s-0031-1283138. Epub 2011 Aug 5. Horm Metab Res. 2011. PMID: 21823054

8

Long-term follow-up and outcome of phenylketonuria patients on sapropterin: a retrospective study.

Keil S, Anjema K, van Spronsen FJ, Lambruschini N, Burlina A, Bélanger-Quintana A, Couce ML, Feillet F, Cerone R, Lotz-Havla AS, Muntau AC, Bosch AM, Meli CA, Billette de Villemeur T, Kern I, Riva E, Giovannini M, Damaj L, Leuzzi V, Blau N. Keil S, et al. Pediatrics. 2013 Jun;131(6):e1881-8. doi: 10.1542/peds.2012-3291. Epub 2013 May 20. Pediatrics. 2013. PMID: 23690520

9

Tao and Rap2l ensure proper Misshapen activation and levels during Drosophila border cell migration.

Roberto GM, Boutet A, Keil S, Del Guidice E, Duramé E, Tremblay MG, Moss T, Therrien M, Emery G. Roberto GM, et al. Among authors: keil s. Dev Cell. 2024 Oct 8:S1534-5807(24)00544-6. doi: 10.1016/j.devcel.2024.09.014. Online ahead of print. Dev Cell. 2024. PMID: 39393350

10

Airing It Out: Variations in Intensive Care Unit Management of Severe Asthma Exacerbations and Differences in Outcome.

Keil S, Hyzy RC. Keil S, et al. Ann Am Thorac Soc. 2024 Oct;21(10):1379-1380. doi: 10.1513/AnnalsATS.202406-669ED. Ann Am Thorac Soc. 2024. PMID: 39352181 Free PMC article. No abstract available.

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