Xu G - Search Results

1

3-(7-Azaindolyl)-4-indolylmaleimides as a novel class of mutant isocitrate dehydrogenase-1 inhibitors: Design, synthesis, and biological evaluation.

Hu Y, Gao A, Liao H, Zhang M, Xu G, Gao L, Xu L, Zhou Y, Gao J, Ye Q, Li J. Hu Y, et al. Among authors: xu l, xu g. Arch Pharm (Weinheim). 2018 Oct;351(10):e1800039. doi: 10.1002/ardp.201800039. Epub 2018 Aug 16. Arch Pharm (Weinheim). 2018. PMID: 30113716

2

Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents.

Lin Y, Xing D, Wu WB, Xu GY, Yu LF, Tang J, Zhou YB, Li J, Yang F. Lin Y, et al. Molecules. 2020 Jan 3;25(1):203. doi: 10.3390/molecules25010203. Molecules. 2020. PMID: 31947824 Free PMC article.

3

Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells.

Che J, Huang F, Zhang M, Xu G, Qu B, Gao J, Chen B, Zhang J, Ying H, Hu Y, Hu X, Zhou Y, Gao A, Li J, Dong X. Che J, et al. Among authors: xu g. Eur J Med Chem. 2020 Oct 1;203:112491. doi: 10.1016/j.ejmech.2020.112491. Epub 2020 Jul 12. Eur J Med Chem. 2020. PMID: 32679449

4

Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity.

Wang Y, Mi T, Li Y, Kan W, Xu G, Li J, Zhou Y, Li J, Jiang X. Wang Y, et al. Among authors: xu g. Eur J Med Chem. 2021 Jan 1;209:112912. doi: 10.1016/j.ejmech.2020.112912. Epub 2020 Oct 10. Eur J Med Chem. 2021. PMID: 33328101

5

Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia.

Jin T, Wang P, Long X, Jiang K, Song P, Wu W, Xu G, Zhou Y, Li J, Liu T. Jin T, et al. Among authors: xu g. ChemMedChem. 2021 May 6;16(9):1477-1487. doi: 10.1002/cmdc.202000882. Epub 2021 Feb 16. ChemMedChem. 2021. PMID: 33591599

6

Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies.

Jiang KL, Tong LX, Wang T, Wang HL, Hu XB, Xu GY, Jin TT, Kan WJ, Xu L, Li JN, Zhang KX, Song N, Liu JY, Zhang MM, Wu WB, Xiang YQ, Gao AH, Hu YZ, Zhou YB, Liu T, Yang JM, Li J. Jiang KL, et al. Acta Pharmacol Sin. 2022 Jan;43(1):220-228. doi: 10.1038/s41401-021-00652-1. Epub 2021 Mar 29. Acta Pharmacol Sin. 2022. PMID: 33782542 Free PMC article.

7

Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity.

Kamoldinov K, Li J, Eshbakova K, Sagdullaev S, Xu G, Zhou Y, Li J, Aisa HA. Kamoldinov K, et al. Among authors: xu g. Phytochemistry. 2021 Jul;187:112705. doi: 10.1016/j.phytochem.2021.112705. Epub 2021 May 3. Phytochemistry. 2021. PMID: 33957541

8

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.

Li C, Su M, Zhu W, Kan W, Ge T, Xu G, Wang S, Sheng L, Gao F, Ye Y, Wang J, Zhou Y, Li J, Liu H. Li C, et al. Among authors: xu g. J Med Chem. 2022 Mar 10;65(5):4335-4349. doi: 10.1021/acs.jmedchem.1c02156. Epub 2022 Feb 24. J Med Chem. 2022. PMID: 35200034

9

Design, Synthesis, and Biological Evaluation of 2-Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors.

Deng M, Wang P, Long X, Xu G, Wang C, Li J, Zhou Y, Liu T. Deng M, et al. Among authors: xu g. ChemMedChem. 2023 Apr 3;18(7):e202200664. doi: 10.1002/cmdc.202200664. Epub 2023 Feb 2. ChemMedChem. 2023. PMID: 36732891

10

Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia.

Wang H, Luo G, Hu X, Xu G, Wang T, Liu M, Qiu X, Li J, Fu J, Feng B, Tu Y, Kan W, Wang C, Xu R, Zhou Y, Yang J, Li J. Wang H, et al. Among authors: xu r, xu g. Nat Commun. 2023 Apr 5;14(1):1882. doi: 10.1038/s41467-023-37381-4. Nat Commun. 2023. PMID: 37019911 Free PMC article.

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