Delgoffe GM - Search Results

1

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted.

Tilstra JS, Avery L, Menk AV, Gordon RA, Smita S, Kane LP, Chikina M, Delgoffe GM, Shlomchik MJ. Tilstra JS, et al. Among authors: delgoffe gm. J Clin Invest. 2018 Nov 1;128(11):4884-4897. doi: 10.1172/JCI120859. Epub 2018 Sep 24. J Clin Invest. 2018. PMID: 30130253 Free PMC article.

2

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. Scharping NE, et al. Among authors: delgoffe gm. Immunity. 2016 Aug 16;45(2):374-88. doi: 10.1016/j.immuni.2016.07.009. Epub 2016 Aug 2. Immunity. 2016. PMID: 27496732 Free PMC article.

3

Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul.

Delgoffe GM. Delgoffe GM. Cancer Immunol Res. 2016 Dec;4(12):1001-1006. doi: 10.1158/2326-6066.CIR-16-0244. Cancer Immunol Res. 2016. PMID: 27908931 Free PMC article. Review.

4

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia.

Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM. Scharping NE, et al. Among authors: delgoffe gm. Cancer Immunol Res. 2017 Jan;5(1):9-16. doi: 10.1158/2326-6066.CIR-16-0103. Epub 2016 Dec 9. Cancer Immunol Res. 2017. PMID: 27941003 Free PMC article.

5

Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions.

Phong B, Avery L, Menk AV, Delgoffe GM, Kane LP. Phong B, et al. Among authors: delgoffe gm. J Immunol. 2017 Jan 15;198(2):640-644. doi: 10.4049/jimmunol.1601150. Epub 2016 Dec 14. J Immunol. 2017. PMID: 27974455 Free PMC article.

6

Interferon-γ Drives T_reg Fragility to Promote Anti-tumor Immunity.

Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Overacre-Delgoffe AE, et al. Among authors: delgoffe gm. Cell. 2017 Jun 1;169(6):1130-1141.e11. doi: 10.1016/j.cell.2017.05.005. Epub 2017 May 25. Cell. 2017. PMID: 28552348 Free PMC article.

7

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

Menk AV, Scharping NE, Moreci RS, Zeng X, Guy C, Salvatore S, Bae H, Xie J, Young HA, Wendell SG, Delgoffe GM. Menk AV, et al. Among authors: delgoffe gm. Cell Rep. 2018 Feb 6;22(6):1509-1521. doi: 10.1016/j.celrep.2018.01.040. Cell Rep. 2018. PMID: 29425506 Free PMC article.

8

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM. Menk AV, et al. Among authors: delgoffe gm. J Exp Med. 2018 Apr 2;215(4):1091-1100. doi: 10.1084/jem.20171068. Epub 2018 Mar 6. J Exp Med. 2018. PMID: 29511066 Free PMC article.

9

IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation.

Revu S, Wu J, Henkel M, Rittenhouse N, Menk A, Delgoffe GM, Poholek AC, McGeachy MJ. Revu S, et al. Among authors: delgoffe gm. Cell Rep. 2018 Mar 6;22(10):2642-2653. doi: 10.1016/j.celrep.2018.02.044. Cell Rep. 2018. PMID: 29514093 Free PMC article.

10

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation.

Vendetti FP, Karukonda P, Clump DA, Teo T, Lalonde R, Nugent K, Ballew M, Kiesel BF, Beumer JH, Sarkar SN, Conrads TP, O'Connor MJ, Ferris RL, Tran PT, Delgoffe GM, Bakkenist CJ. Vendetti FP, et al. Among authors: delgoffe gm. J Clin Invest. 2018 Aug 31;128(9):3926-3940. doi: 10.1172/JCI96519. Epub 2018 Aug 13. J Clin Invest. 2018. PMID: 29952768 Free PMC article.

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