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Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.
Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM. Liang YL, et al. Among authors: hay dl. Nature. 2018 Sep;561(7724):492-497. doi: 10.1038/s41586-018-0535-y. Epub 2018 Sep 12. Nature. 2018. PMID: 30209400 Free PMC article.
GPCR modulation by RAMPs.
Hay DL, Poyner DR, Sexton PM. Hay DL, et al. Pharmacol Ther. 2006 Jan;109(1-2):173-97. doi: 10.1016/j.pharmthera.2005.06.015. Epub 2005 Aug 18. Pharmacol Ther. 2006. PMID: 16111761 Review.
Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors--the role of receptor activity modifying protein 1.
Hay DL, Christopoulos G, Christopoulos A, Sexton PM. Hay DL, et al. Mol Pharmacol. 2006 Dec;70(6):1984-91. doi: 10.1124/mol.106.027953. Epub 2006 Sep 7. Mol Pharmacol. 2006. PMID: 16959943
196 results