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The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, Wiltfang J, Becker-Pauly C, Beher D, Pietrzik CU, Fraering PC, Wirths O, Weggen S. Walter S, et al. Among authors: jumpertz t. Acta Neuropathol. 2019 Feb;137(2):239-257. doi: 10.1007/s00401-018-1929-5. Epub 2018 Nov 13. Acta Neuropathol. 2019. PMID: 30426203
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.
Jefferson T, Čaušević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. Jefferson T, et al. Among authors: jumpertz t. J Biol Chem. 2011 Aug 5;286(31):27741-50. doi: 10.1074/jbc.M111.252718. Epub 2011 Jun 6. J Biol Chem. 2011. PMID: 21646356 Free PMC article.
Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Goel P, Jumpertz T, Mikles DC, Tichá A, Nguyen MTN, Verhelst S, Hubalek M, Johnson DC, Bachovchin DA, Ogorek I, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S. Goel P, et al. Among authors: jumpertz t. Biochemistry. 2017 Dec 26;56(51):6713-6725. doi: 10.1021/acs.biochem.7b01066. Epub 2017 Dec 12. Biochemistry. 2017. PMID: 29185711 Free PMC article.
15 results