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The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.
Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao EC. Barruet E, et al. Among authors: morales bm. Stem Cell Res Ther. 2016 Aug 17;7(1):115. doi: 10.1186/s13287-016-0372-6. Stem Cell Res Ther. 2016. PMID: 27530160 Free PMC article.
ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC. Yu X, et al. Among authors: morales bm. Pain. 2023 Jan 1;164(1):43-58. doi: 10.1097/j.pain.0000000000002656. Epub 2022 Apr 20. Pain. 2023. PMID: 35442931 Free PMC article.
Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures.
Pennings I, van Dijk LA, van Huuksloot J, Fledderus JO, Schepers K, Braat AK, Hsiao EC, Barruet E, Morales BM, Verhaar MC, Rosenberg AJWP, Gawlitta D. Pennings I, et al. Among authors: morales bm. J Tissue Eng Regen Med. 2019 Mar;13(3):433-445. doi: 10.1002/term.2807. Epub 2019 Feb 8. J Tissue Eng Regen Med. 2019. PMID: 30650247 Free PMC article.
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.
Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M. Casanova-Acebes M, et al. Among authors: morales bm. Nature. 2021 Jul;595(7868):578-584. doi: 10.1038/s41586-021-03651-8. Epub 2021 Jun 16. Nature. 2021. PMID: 34135508 Free PMC article.