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Page 1
Programmable design of orthogonal protein heterodimers.
Chen Z, Boyken SE, Jia M, Busch F, Flores-Solis D, Bick MJ, Lu P, VanAernum ZL, Sahasrabuddhe A, Langan RA, Bermeo S, Brunette TJ, Mulligan VK, Carter LP, DiMaio F, Sgourakis NG, Wysocki VH, Baker D. Chen Z, et al. Among authors: lu p. Nature. 2019 Jan;565(7737):106-111. doi: 10.1038/s41586-018-0802-y. Epub 2018 Dec 19. Nature. 2019. PMID: 30568301 Free PMC article.
Accurate computational design of multipass transmembrane proteins.
Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D. Lu P, et al. Science. 2018 Mar 2;359(6379):1042-1046. doi: 10.1126/science.aaq1739. Science. 2018. PMID: 29496880 Free PMC article.
Structural basis for gating pore current in periodic paralysis.
Jiang D, Gamal El-Din TM, Ing C, Lu P, Pomès R, Zheng N, Catterall WA. Jiang D, et al. Among authors: lu p. Nature. 2018 May;557(7706):590-594. doi: 10.1038/s41586-018-0120-4. Epub 2018 May 16. Nature. 2018. PMID: 29769724 Free PMC article.
Crystal structure of a membrane-bound O-acyltransferase.
Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W. Ma D, et al. Among authors: lu p. Nature. 2018 Oct;562(7726):286-290. doi: 10.1038/s41586-018-0568-2. Epub 2018 Oct 3. Nature. 2018. PMID: 30283133 Free PMC article.
Computational design of transmembrane pores.
Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch EM, Boyken SE, Huang PS, Stewart L, DiMaio F, Kollman JM, Luisi BF, Matsuura T, Catterall WA, Baker D. Xu C, et al. Among authors: lu p. Nature. 2020 Sep;585(7823):129-134. doi: 10.1038/s41586-020-2646-5. Epub 2020 Aug 26. Nature. 2020. PMID: 32848250 Free PMC article.
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Hosseinzadeh P, Watson PR, Craven TW, Li X, Rettie S, Pardo-Avila F, Bera AK, Mulligan VK, Lu P, Ford AS, Weitzner BD, Stewart LJ, Moyer AP, Di Piazza M, Whalen JG, Greisen PJ, Christianson DW, Baker D. Hosseinzadeh P, et al. Among authors: lu p. Nat Commun. 2021 Jun 7;12(1):3384. doi: 10.1038/s41467-021-23609-8. Nat Commun. 2021. PMID: 34099674 Free PMC article.
Accurate de novo design of heterochiral protein-protein interactions.
Sun K, Li S, Zheng B, Zhu Y, Wang T, Liang M, Yao Y, Zhang K, Zhang J, Li H, Han D, Zheng J, Coventry B, Cao L, Baker D, Liu L, Lu P. Sun K, et al. Among authors: lu p. Cell Res. 2024 Aug 14. doi: 10.1038/s41422-024-01014-2. Online ahead of print. Cell Res. 2024. PMID: 39143121
6,931 results