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Hsp90 activator Aha1 drives production of pathological tau aggregates.
Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J 3rd, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA. Shelton LB, et al. Among authors: baker jd. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9707-9712. doi: 10.1073/pnas.1707039114. Epub 2017 Aug 21. Proc Natl Acad Sci U S A. 2017. PMID: 28827321 Free PMC article.
Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.
Sabbagh JJ, Cordova RA, Zheng D, Criado-Marrero M, Lemus A, Li P, Baker JD, Nordhues BA, Darling AL, Martinez-Licha C, Rutz DA, Patel S, Buchner J, Leahy JW, Koren J 3rd, Dickey CA, Blair LJ. Sabbagh JJ, et al. Among authors: baker jd. ACS Chem Biol. 2018 Aug 17;13(8):2288-2299. doi: 10.1021/acschembio.8b00454. Epub 2018 Jun 19. ACS Chem Biol. 2018. PMID: 29893552 Free PMC article.
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.
Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M. Oroz J, et al. Among authors: baker jd. Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0. Nat Commun. 2018. PMID: 30382094 Free PMC article.
Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, Selenica MB, Nash KR, Gordon MN, Morgan D, Lee DC. Sandusky-Beltran LA, et al. Among authors: baker jd. Alzheimers Res Ther. 2019 Jun 29;11(1):58. doi: 10.1186/s13195-019-0507-y. Alzheimers Res Ther. 2019. PMID: 31253191 Free PMC article.
375 results