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The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
Christian S, Merz C, Evans L, Gradl S, Seidel H, Friberg A, Eheim A, Lejeune P, Brzezinka K, Zimmermann K, Ferrara S, Meyer H, Lesche R, Stoeckigt D, Bauser M, Haegebarth A, Sykes DB, Scadden DT, Losman JA, Janzer A. Christian S, et al. Among authors: brzezinka k. Leukemia. 2019 Oct;33(10):2403-2415. doi: 10.1038/s41375-019-0461-5. Epub 2019 Apr 2. Leukemia. 2019. PMID: 30940908
Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target.
Brzezinka K, Nevedomskaya E, Lesche R, Haegebarth A, Ter Laak A, Fernández-Montalván AE, Eberspaecher U, Werbeck ND, Moenning U, Siegel S, Haendler B, Eheim AL, Stresemann C. Brzezinka K, et al. Cancers (Basel). 2020 Jan 14;12(1):201. doi: 10.3390/cancers12010201. Cancers (Basel). 2020. PMID: 31947537 Free PMC article.
15 results