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Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart.
Zhang Y, Wang WE, Zhang X, Li Y, Chen B, Liu C, Ai X, Zhang X, Tian Y, Zhang C, Tang M, Szeto C, Hua X, Xie M, Zeng C, Wu Y, Zhou L, Zhu W, Yu D, Houser SR, Chen X. Zhang Y, et al. Among authors: zhang c, zhang x. Circ Res. 2019 Jun 7;124(12):1760-1777. doi: 10.1161/CIRCRESAHA.118.313417. Epub 2019 Apr 15. Circ Res. 2019. PMID: 30982412
Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties.
Chen X, Wilson RM, Kubo H, Berretta RM, Harris DM, Zhang X, Jaleel N, MacDonnell SM, Bearzi C, Tillmanns J, Trofimova I, Hosoda T, Mosna F, Cribbs L, Leri A, Kajstura J, Anversa P, Houser SR. Chen X, et al. Among authors: zhang x. Circ Res. 2007 Mar 2;100(4):536-44. doi: 10.1161/01.RES.0000259560.39234.99. Epub 2007 Feb 1. Circ Res. 2007. PMID: 17272809
Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity.
Tang M, Zhang X, Li Y, Guan Y, Ai X, Szeto C, Nakayama H, Zhang H, Ge S, Molkentin JD, Houser SR, Chen X. Tang M, et al. Among authors: zhang x, zhang h. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H519-28. doi: 10.1152/ajpheart.00265.2010. Epub 2010 Jun 11. Am J Physiol Heart Circ Physiol. 2010. PMID: 20543081 Free PMC article.
Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction.
Zhang H, Chen X, Gao E, MacDonnell SM, Wang W, Kolpakov M, Nakayama H, Zhang X, Jaleel N, Harris DM, Li Y, Tang M, Berretta R, Leri A, Kajstura J, Sabri A, Koch WJ, Molkentin JD, Houser SR. Zhang H, et al. Among authors: zhang x. Circ Res. 2010 Sep 17;107(6):800-9. doi: 10.1161/CIRCRESAHA.110.219220. Epub 2010 Jul 29. Circ Res. 2010. PMID: 20671241 Free PMC article.
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Chen X, et al. Among authors: zhang x, zhang h. J Mol Cell Cardiol. 2011 Mar;50(3):460-70. doi: 10.1016/j.yjmcc.2010.11.012. Epub 2010 Nov 25. J Mol Cell Cardiol. 2011. PMID: 21111744 Free PMC article.
Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.
Raake PW, Zhang X, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Dorn GW 2nd, Houser SR, Katus HA, Chen X, Koch WJ. Raake PW, et al. Among authors: zhang x. Circulation. 2012 May 1;125(17):2108-18. doi: 10.1161/CIRCULATIONAHA.111.044255. Epub 2012 Apr 10. Circulation. 2012. PMID: 22496128 Free PMC article.
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