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Page 1
Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis.
Ovadia C, Perdones-Montero A, Spagou K, Smith A, Sarafian MH, Gomez-Romero M, Bellafante E, Clarke LCD, Sadiq F, Nikolova V, Mitchell A, Dixon PH, Santa-Pinter N, Wahlström A, Abu-Hayyeh S, Walters JRF, Marschall HU, Holmes E, Marchesi JR, Williamson C. Ovadia C, et al. Among authors: abu hayyeh s. Hepatology. 2019 Jul;70(1):276-293. doi: 10.1002/hep.30661. Epub 2019 May 21. Hepatology. 2019. PMID: 30983011 Free PMC article.
Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype.
Abu-Hayyeh S, Papacleovoulou G, Lövgren-Sandblom A, Tahir M, Oduwole O, Jamaludin NA, Ravat S, Nikolova V, Chambers J, Selden C, Rees M, Marschall HU, Parker MG, Williamson C. Abu-Hayyeh S, et al. Hepatology. 2013 Feb;57(2):716-26. doi: 10.1002/hep.26055. Epub 2013 Jan 8. Hepatology. 2013. PMID: 22961653 Free PMC article.
Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum.
Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lövgren-Sandblom A, Bolier R, Tolenaars D, Kremer AE, Syngelaki A, Noori M, Williams D, Marin JJ, Monte MJ, Nicolaides KH, Beuers U, Oude-Elferink R, Seed PT, Chappell L, Marschall HU, Bunnett NW, Williamson C. Abu-Hayyeh S, et al. Hepatology. 2016 Apr;63(4):1287-98. doi: 10.1002/hep.28265. Epub 2015 Dec 28. Hepatology. 2016. PMID: 26426865 Free PMC article.
Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy.
Borges Manna L, Papacleovoulou G, Flaviani F, Pataia V, Qadri A, Abu-Hayyeh S, McIlvride S, Jansen E, Dixon P, Chambers J, Vazquez-Lopez M, Wahlström A, Kitaba N, Marschall HU, Godfrey KM, Lillycrop K, Williamson C. Borges Manna L, et al. Among authors: abu hayyeh s. Sci Rep. 2020 Jun 25;10(1):10361. doi: 10.1038/s41598-020-67301-1. Sci Rep. 2020. PMID: 32587408 Free PMC article.
Maternal cholestasis during pregnancy programs metabolic disease in offspring.
Papacleovoulou G, Abu-Hayyeh S, Nikolopoulou E, Briz O, Owen BM, Nikolova V, Ovadia C, Huang X, Vaarasmaki M, Baumann M, Jansen E, Albrecht C, Jarvelin MR, Marin JJ, Knisely AS, Williamson C. Papacleovoulou G, et al. Among authors: abu hayyeh s. J Clin Invest. 2013 Jul;123(7):3172-81. doi: 10.1172/JCI68927. Epub 2013 Jun 24. J Clin Invest. 2013. PMID: 23934127 Free PMC article.
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