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Synergic PDE3 and PDE4 control intracellular cAMP and cardiac excitation-contraction coupling in a porcine model.
Mika D, Bobin P, Lindner M, Boet A, Hodzic A, Lefebvre F, Lechène P, Sadoune M, Samuel JL, Algalarrondo V, Rucker-Martin C, Lambert V, Fischmeister R, Vandecasteele G, Leroy J. Mika D, et al. Among authors: lechene p. J Mol Cell Cardiol. 2019 Aug;133:57-66. doi: 10.1016/j.yjmcc.2019.05.025. Epub 2019 May 31. J Mol Cell Cardiol. 2019. PMID: 31158360
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Mehel H, et al. Among authors: lechene p. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. J Am Coll Cardiol. 2013. PMID: 23810893 Free article.
Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.
Cazabat L, Ragazzon B, Varin A, Potier-Cartereau M, Vandier C, Vezzosi D, Risk-Rabin M, Guellich A, Schittl J, Lechêne P, Richter W, Nikolaev VO, Zhang J, Bertherat J, Vandecasteele G. Cazabat L, et al. Among authors: lechene p. Hum Mol Genet. 2014 Mar 1;23(5):1163-74. doi: 10.1093/hmg/ddt510. Epub 2013 Oct 10. Hum Mol Genet. 2014. PMID: 24122441 Free PMC article.
Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.
Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Haj Slimane Z, et al. Among authors: lechene p. Cardiovasc Res. 2014 Apr 1;102(1):97-106. doi: 10.1093/cvr/cvu029. Epub 2014 Feb 18. Cardiovasc Res. 2014. PMID: 24550350 Free PMC article.
38 results