Scharping NE - Search Results

1

IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell.

Shao L, Hou W, Scharping NE, Vendetti FP, Srivastava R, Roy CN, Menk AV, Wang Y, Chauvin JM, Karukonda P, Thorne SH, Hornung V, Zarour HM, Bakkenist CJ, Delgoffe GM, Sarkar SN. Shao L, et al. Among authors: scharping ne. Cancer Immunol Res. 2019 Aug;7(8):1258-1266. doi: 10.1158/2326-6066.CIR-18-0711. Epub 2019 Jun 25. Cancer Immunol Res. 2019. PMID: 31239318 Free PMC article.

2

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. Scharping NE, et al. Immunity. 2016 Aug 16;45(2):374-88. doi: 10.1016/j.immuni.2016.07.009. Epub 2016 Aug 2. Immunity. 2016. PMID: 27496732 Free PMC article.

3

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. Scharping NE, et al. Immunity. 2016 Sep 20;45(3):701-703. doi: 10.1016/j.immuni.2016.08.009. Epub 2016 Sep 20. Immunity. 2016. PMID: 27653602 Free article. No abstract available.

4

Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity.

Scharping NE, Delgoffe GM. Scharping NE, et al. Vaccines (Basel). 2016 Dec 6;4(4):46. doi: 10.3390/vaccines4040046. Vaccines (Basel). 2016. PMID: 27929420 Free PMC article. Review.

5

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia.

Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM. Scharping NE, et al. Cancer Immunol Res. 2017 Jan;5(1):9-16. doi: 10.1158/2326-6066.CIR-16-0103. Epub 2016 Dec 9. Cancer Immunol Res. 2017. PMID: 27941003 Free PMC article.

6

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

Menk AV, Scharping NE, Moreci RS, Zeng X, Guy C, Salvatore S, Bae H, Xie J, Young HA, Wendell SG, Delgoffe GM. Menk AV, et al. Among authors: scharping ne. Cell Rep. 2018 Feb 6;22(6):1509-1521. doi: 10.1016/j.celrep.2018.01.040. Cell Rep. 2018. PMID: 29425506 Free PMC article.

7

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM. Menk AV, et al. Among authors: scharping ne. J Exp Med. 2018 Apr 2;215(4):1091-1100. doi: 10.1084/jem.20171068. Epub 2018 Mar 6. J Exp Med. 2018. PMID: 29511066 Free PMC article.

8

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion.

Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, Peralta R, Wang Y, Wang Y, DePeaux K, Poholek AC, Delgoffe GM. Scharping NE, et al. Nat Immunol. 2021 Feb;22(2):205-215. doi: 10.1038/s41590-020-00834-9. Epub 2021 Jan 4. Nat Immunol. 2021. PMID: 33398183 Free PMC article.

9

Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells.

Ford BR, Vignali PDA, Rittenhouse NL, Scharping NE, Peralta R, Lontos K, Frisch AT, Delgoffe GM, Poholek AC. Ford BR, et al. Among authors: scharping ne. Sci Immunol. 2022 Aug 5;7(74):eabj9123. doi: 10.1126/sciimmunol.abj9123. Epub 2022 Aug 5. Sci Immunol. 2022. PMID: 35930654 Free PMC article.

10

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity.

Vignali PDA, DePeaux K, Watson MJ, Ye C, Ford BR, Lontos K, McGaa NK, Scharping NE, Menk AV, Robson SC, Poholek AC, Rivadeneira DB, Delgoffe GM. Vignali PDA, et al. Among authors: scharping ne. Nat Immunol. 2023 Feb;24(2):267-279. doi: 10.1038/s41590-022-01379-9. Epub 2022 Dec 21. Nat Immunol. 2023. PMID: 36543958 Free PMC article.

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