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Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers.
Toledo FGS, Martin WF, Morrow L, Beysen C, Bajorunas D, Jiang Y, Silverman BL, McDonnell D, Namchuk MN, Newcomer JW, Graham C. Toledo FGS, et al. Among authors: namchuk mn. Neuropsychopharmacology. 2022 Feb;47(3):696-703. doi: 10.1038/s41386-021-01244-7. Epub 2021 Dec 9. Neuropsychopharmacology. 2022. PMID: 34887529 Free PMC article. Clinical Trial.
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Gold ER, Ali-Khan SE, Allen L, Ballell L, Barral-Netto M, Carr D, Chalaud D, Chaplin S, Clancy MS, Clarke P, Cook-Deegan R, Dinsmore AP, Doerr M, Federer L, Hill SA, Jacobs N, Jean A, Jefferson OA, Jones C, Kahl LJ, Kariuki TM, Kassel SN, Kiley R, Kittrie ER, Kramer B, Lee WH, MacDonald E, Mangravite LM, Marincola E, Mietchen D, Molloy JC, Namchuk M, Nosek BA, Paquet S, Pirmez C, Seyller A, Skingle M, Spadotto SN, Staniszewska S, Thelwall M. Gold ER, et al. Among authors: namchuk m. Gates Open Res. 2019 Apr 30;3:1442. doi: 10.12688/gatesopenres.12958.2. eCollection 2019. Gates Open Res. 2019. PMID: 31850398 Free PMC article.
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18.
Wannamaker W, Davies R, Namchuk M, Pollard J, Ford P, Ku G, Decker C, Charifson P, Weber P, Germann UA, Kuida K, Randle JC. Wannamaker W, et al. Among authors: namchuk m. J Pharmacol Exp Ther. 2007 May;321(2):509-16. doi: 10.1124/jpet.106.111344. Epub 2007 Feb 8. J Pharmacol Exp Ther. 2007. PMID: 17289835
Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease.
MacDonald EA, Frey G, Namchuk MN, Harrison SC, Hinshaw SM, Windsor IW. MacDonald EA, et al. Among authors: namchuk mn. ACS Infect Dis. 2021 Sep 10;7(9):2591-2595. doi: 10.1021/acsinfecdis.1c00237. Epub 2021 Aug 26. ACS Infect Dis. 2021. PMID: 34437808 Free PMC article.
34 results