Prakash TP - Search Results

1

Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models.

Kim Y, Jo M, Schmidt J, Luo X, Prakash TP, Zhou T, Klein S, Xiao X, Post N, Yin Z, MacLeod AR. Kim Y, et al. Among authors: prakash tp. Mol Ther. 2019 Sep 4;27(9):1547-1557. doi: 10.1016/j.ymthe.2019.06.009. Epub 2019 Jun 29. Mol Ther. 2019. PMID: 31303442 Free PMC article.

2

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys.

Shemesh CS, Yu RZ, Gaus HJ, Greenlee S, Post N, Schmidt K, Migawa MT, Seth PP, Zanardi TA, Prakash TP, Swayze EE, Henry SP, Wang Y. Shemesh CS, et al. Among authors: prakash tp. Mol Ther Nucleic Acids. 2016 May 10;5(5):e319. doi: 10.1038/mtna.2016.31. Mol Ther Nucleic Acids. 2016. PMID: 27164023 Free PMC article.

3

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.

Yu RZ, Gunawan R, Post N, Zanardi T, Hall S, Burkey J, Kim TW, Graham MJ, Prakash TP, Seth PP, Swayze EE, Geary RS, Henry SP, Wang Y. Yu RZ, et al. Among authors: prakash tp. Nucleic Acid Ther. 2016 Dec;26(6):372-380. doi: 10.1089/nat.2016.0623. Epub 2016 Aug 8. Nucleic Acid Ther. 2016. PMID: 27500733

4

Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.

Yu RZ, Graham MJ, Post N, Riney S, Zanardi T, Hall S, Burkey J, Shemesh CS, Prakash TP, Seth PP, Swayze EE, Geary RS, Wang Y, Henry S. Yu RZ, et al. Among authors: prakash tp. Mol Ther Nucleic Acids. 2016 May 3;5(5):e317. doi: 10.1038/mtna.2016.26. Mol Ther Nucleic Acids. 2016. PMID: 27138177 Free PMC article.

5

Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice.

Chappell AE, Gaus HJ, Berdeja A, Gupta R, Jo M, Prakash TP, Oestergaard M, Swayze EE, Seth PP. Chappell AE, et al. Among authors: prakash tp. Nucleic Acids Res. 2020 May 7;48(8):4382-4395. doi: 10.1093/nar/gkaa164. Nucleic Acids Res. 2020. PMID: 32182359 Free PMC article.

6

Evaluation of the effect of 2'-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice.

Prakash TP, Yu J, Kinberger GA, Low A, Jackson M, Rigo F, Swayze EE, Seth PP. Prakash TP, et al. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3774-3779. doi: 10.1016/j.bmcl.2018.10.011. Epub 2018 Oct 10. Bioorg Med Chem Lett. 2018. PMID: 30342955

7

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes.

Tanowitz M, Hettrick L, Revenko A, Kinberger GA, Prakash TP, Seth PP. Tanowitz M, et al. Among authors: prakash tp. Nucleic Acids Res. 2017 Dec 1;45(21):12388-12400. doi: 10.1093/nar/gkx960. Nucleic Acids Res. 2017. PMID: 29069408 Free PMC article.

8

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.

Kinberger GA, Prakash TP, Yu J, Vasquez G, Low A, Chappell A, Schmidt K, Murray HM, Gaus H, Swayze EE, Seth PP. Kinberger GA, et al. Among authors: prakash tp. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3690-3. doi: 10.1016/j.bmcl.2016.05.084. Epub 2016 May 28. Bioorg Med Chem Lett. 2016. PMID: 27268307

9

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.

Schmidt K, Prakash TP, Donner AJ, Kinberger GA, Gaus HJ, Low A, Østergaard ME, Bell M, Swayze EE, Seth PP. Schmidt K, et al. Among authors: prakash tp. Nucleic Acids Res. 2017 Mar 17;45(5):2294-2306. doi: 10.1093/nar/gkx060. Nucleic Acids Res. 2017. PMID: 28158620 Free PMC article.

10

Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides.

Østergaard ME, Yu J, Kinberger GA, Wan WB, Migawa MT, Vasquez G, Schmidt K, Gaus HJ, Murray HM, Low A, Swayze EE, Prakash TP, Seth PP. Østergaard ME, et al. Among authors: prakash tp. Bioconjug Chem. 2015 Aug 19;26(8):1451-5. doi: 10.1021/acs.bioconjchem.5b00265. Epub 2015 Jun 10. Bioconjug Chem. 2015. PMID: 26011654

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