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Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.
Kalel VC, Li M, Gaussmann S, Delhommel F, Schäfer AB, Tippler B, Jung M, Maier R, Oeljeklaus S, Schliebs W, Warscheid B, Sattler M, Erdmann R. Kalel VC, et al. Among authors: tippler b. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118520. doi: 10.1016/j.bbamcr.2019.07.015. Epub 2019 Jul 29. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31369765 Free article.
Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM. Dawidowski M, et al. Among authors: tippler b. J Med Chem. 2020 Jan 23;63(2):847-879. doi: 10.1021/acs.jmedchem.9b01876. Epub 2020 Jan 6. J Med Chem. 2020. PMID: 31860309
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
Napolitano V, Mróz P, Marciniak M, Kalel VC, Softley CA, Janna Olmos JD, Tippler BG, Schorpp K, Rioton S, Fröhlich T, Plettenburg O, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dawidowski M, Dubin G. Napolitano V, et al. Among authors: tippler bg. Eur J Med Chem. 2022 Dec 5;243:114778. doi: 10.1016/j.ejmech.2022.114778. Epub 2022 Sep 27. Eur J Med Chem. 2022. PMID: 36194937 Free article.
25 results