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3,166 results

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Page 1
Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Guo Y, Liu Y, Hu N, Yu D, Zhou C, Shi G, Zhang B, Wei M, Liu J, Luo L, Tang Z, Song H, Guo Y, Liu X, Su D, Zhang S, Song X, Zhou X, Hong Y, Chen S, Cheng Z, Young S, Wei Q, Wang H, Wang Q, Lv L, Wang F, Xu H, Sun H, Xing H, Li N, Zhang W, Wang Z, Liu G, Sun Z, Zhou D, Li W, Liu L, Wang L, Wang Z. Guo Y, et al. Among authors: hu n. J Med Chem. 2019 Sep 12;62(17):7923-7940. doi: 10.1021/acs.jmedchem.9b00687. Epub 2019 Aug 19. J Med Chem. 2019. PMID: 31381333
Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma.
Flinsenberg TWH, Tromedjo CC, Hu N, Liu Y, Guo Y, Thia KYT, Noori T, Song X, Aw Yeang HX, Tantalo DG, Handunnetti S, Seymour JF, Roberts AW, Ritchie D, Koldej R, Neeson PJ, Wang L, Trapani JA, Tam CS, Voskoboinik I. Flinsenberg TWH, et al. Among authors: hu n. Haematologica. 2020 Jan 31;105(2):e76-e79. doi: 10.3324/haematol.2019.220590. Print 2020. Haematologica. 2020. PMID: 31171645 Free PMC article. No abstract available.
Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases.
Guo Y, Hu N, Liu Y, Zhang W, Yu D, Shi G, Zhang B, Yin L, Wei M, Yuan X, Luo L, Wang F, Song X, Xin L, Wei Q, Li Y, Guo Y, Chen S, Zhang T, Zhang S, Zhou X, Zhang C, Su D, Liu J, Cheng Z, Zhang J, Xing H, Sun H, Li X, Zhao Y, He M, Wu Y, Guo Y, Sun X, Tian A, Zhou C, Young S, Liu X, Wang L, Wang Z. Guo Y, et al. Among authors: hu n. J Med Chem. 2023 Mar 23;66(6):4025-4044. doi: 10.1021/acs.jmedchem.2c01938. Epub 2023 Mar 13. J Med Chem. 2023. PMID: 36912866
Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Liu J, Li S, Wang Q, Feng Y, Xing H, Yang X, Guo Y, Guo Y, Sun H, Liu X, Yang S, Mei Z, Zhu Y, Cheng Z, Chen S, Xu M, Zhang W, Wan N, Wang J, Ma Y, Zhang S, Luan X, Xu A, Li L, Wang H, Yang X, Hong Y, Xue H, Yuan X, Hu N, Song X, Wang Z, Liu X, Wang L, Liu Y. Liu J, et al. Among authors: hu n. Blood. 2024 May 2;143(18):1825-1836. doi: 10.1182/blood.2023019706. Blood. 2024. PMID: 38211332 Free PMC article.
Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2.
Guo Y, Xue H, Hu N, Liu Y, Sun H, Yu D, Qin L, Shi G, Wang F, Xin L, Sun W, Zhang F, Song X, Li S, Wei Q, Guo Y, Li Y, Liu X, Chen S, Zhang T, Wu Y, Su D, Zhu Y, Xu A, Xu H, Yang S, Zheng Z, Liu J, Yang X, Yuan X, Hong Y, Sun X, Guo Y, Zhou C, Liu X, Wang L, Wang Z. Guo Y, et al. Among authors: hu n. J Med Chem. 2024 May 23;67(10):7836-7858. doi: 10.1021/acs.jmedchem.4c00027. Epub 2024 May 2. J Med Chem. 2024. PMID: 38695063 Free PMC article.
A highly selective PI3Kδ inhibitor BGB-10188 shows superior preclinical anti-tumor activities and decreased on-target side effects on colon.
Yang X, Bai H, Yuan X, Yang X, Liu Y, Guo M, Hu N, Jiang B, Lian Z, Ma Z, Wang J, Sun X, Zhang T, Su D, Wu Y, Li J, Wang F, Wang Z, Wang L, Liu X, Song X. Yang X, et al. Among authors: hu n. Neoplasia. 2024 Nov;57:101053. doi: 10.1016/j.neo.2024.101053. Epub 2024 Sep 10. Neoplasia. 2024. PMID: 39260132 Free PMC article.
Design of dinuclear osmium complex doped antifouling cellulose nanoparticles for targeting and dual photodynamic/photothermal therapy under near infrared irradiation.
Xiong X, Luo X, Zhao C, Hu N, Fang J, Zhang E, Zeng Y, Huang Y, Huang B, Li Y, Wu P, Wang H, Zou Q, Ye W, Wang S. Xiong X, et al. Among authors: hu n. Int J Biol Macromol. 2024 Nov 11:137544. doi: 10.1016/j.ijbiomac.2024.137544. Online ahead of print. Int J Biol Macromol. 2024. PMID: 39537069
Mammographic density in relation to breast cancer risk factors among Chinese women.
Koka H, Tian Y, Deng L, Yu K, Li EN, Guo C, Guida JL, Sung H, Chan A, Hu N, Lu N, Gierach GL, Li J, Yang XR. Koka H, et al. Among authors: hu n. Cancer Epidemiol Biomarkers Prev. 2024 Nov 13. doi: 10.1158/1055-9965.EPI-24-1065. Online ahead of print. Cancer Epidemiol Biomarkers Prev. 2024. PMID: 39535536
3,166 results