Geukens N - Search Results

1

Bridging the Clinical Gap for DNA-Based Antibody Therapy Through Translational Studies in Sheep.

Hollevoet K, De Vleeschauwer S, De Smidt E, Vermeire G, Geukens N, Declerck P. Hollevoet K, et al. Among authors: geukens n. Hum Gene Ther. 2019 Nov;30(11):1431-1443. doi: 10.1089/hum.2019.128. Epub 2019 Sep 10. Hum Gene Ther. 2019. PMID: 31382777

2

DNA-Based Delivery of Checkpoint Inhibitors in Muscle and Tumor Enables Long-Term Responses with Distinct Exposure.

Jacobs L, De Smidt E, Geukens N, Declerck P, Hollevoet K. Jacobs L, et al. Among authors: geukens n. Mol Ther. 2020 Apr 8;28(4):1068-1077. doi: 10.1016/j.ymthe.2020.02.007. Epub 2020 Feb 13. Mol Ther. 2020. PMID: 32101701 Free PMC article.

3

DNA-based delivery of anti-DR5 Nanobodies improves exposure and anti-tumor efficacy over protein-based administration.

Vermeire G, De Smidt E, Casteels P, Geukens N, Declerck P, Hollevoet K. Vermeire G, et al. Among authors: geukens n. Cancer Gene Ther. 2021 Aug;28(7-8):828-838. doi: 10.1038/s41417-020-0204-9. Epub 2020 Jul 30. Cancer Gene Ther. 2021. PMID: 32733055

4

Improved Potency and Safety of DNA-Encoded Antibody Therapeutics Through Plasmid Backbone and Expression Cassette Engineering.

Vermeire G, De Smidt E, Geukens N, Williams JA, Declerck P, Hollevoet K. Vermeire G, et al. Among authors: geukens n. Hum Gene Ther. 2021 Oct;32(19-20):1200-1209. doi: 10.1089/hum.2021.105. Hum Gene Ther. 2021. PMID: 34482757

5

Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response.

Jacobs L, Yshii L, Junius S, Geukens N, Liston A, Hollevoet K, Declerck P. Jacobs L, et al. Among authors: geukens n. Cancer Gene Ther. 2022 Jul;29(7):984-992. doi: 10.1038/s41417-021-00403-8. Epub 2021 Nov 9. Cancer Gene Ther. 2022. PMID: 34754076

6

Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model.

Hollevoet K, Thomas D, Compernolle G, Vermeire G, De Smidt E, De Vleeschauwer S, Smith TRF, Fisher PD, Dewilde M, Geukens N, Declerck P. Hollevoet K, et al. Among authors: geukens n. Front Oncol. 2022 Oct 3;12:1017612. doi: 10.3389/fonc.2022.1017612. eCollection 2022. Front Oncol. 2022. PMID: 36263202 Free PMC article.

7

Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies.

Hollevoet K, De Smidt E, Geukens N, Declerck P. Hollevoet K, et al. Among authors: geukens n. Oncotarget. 2018 Feb 6;9(17):13623-13636. doi: 10.18632/oncotarget.24426. eCollection 2018 Mar 2. Oncotarget. 2018. PMID: 29568382 Free PMC article.

8

Electroporation outperforms in vivo-jetPEI for intratumoral DNA-based reporter gene transfer.

Jacobs L, De Smidt E, Geukens N, Declerck P, Hollevoet K. Jacobs L, et al. Among authors: geukens n. Sci Rep. 2020 Nov 11;10(1):19532. doi: 10.1038/s41598-020-75206-2. Sci Rep. 2020. PMID: 33177564 Free PMC article.

9

Development of a universal anti-adalimumab antibody standard for interlaboratory harmonization.

Gils A, Vande Casteele N, Poppe R, Van de Wouwer M, Compernolle G, Peeters M, Brouwers E, Vermeire S, Geukens N, Declerck PJ. Gils A, et al. Among authors: geukens n. Ther Drug Monit. 2014 Oct;36(5):669-73. doi: 10.1097/FTD.0000000000000074. Ther Drug Monit. 2014. PMID: 24906181 Free PMC article.

10

Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model.

Imbrechts M, Maes W, Ampofo L, Van den Berghe N, Calcoen B, Van Looveren D, Kerstens W, Rasulova M, Vercruysse T, Noppen S, Abdelnabi R, Foo C, Hollevoet K, Maes P, Zhang X, Jochmans D, Ven K, Lammertyn J, Vanhoorelbeke K, Callewaert N, De Munter P, Schols D, Thibaut HJ, Neyts J, Declerck P, Geukens N. Imbrechts M, et al. Among authors: geukens n. iScience. 2022 Aug 19;25(8):104705. doi: 10.1016/j.isci.2022.104705. Epub 2022 Jul 3. iScience. 2022. PMID: 35813873 Free PMC article.

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