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Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT 4th, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Briseño CG, Grajales-Reyes GE, Wöhner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM. Durai V, et al. Among authors: huang x. Nat Immunol. 2019 Sep;20(9):1161-1173. doi: 10.1038/s41590-019-0450-x. Epub 2019 Aug 12. Nat Immunol. 2019. PMID: 31406378 Free PMC article.
An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.
Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM. Bagadia P, et al. Among authors: huang x. Nat Immunol. 2019 Sep;20(9):1174-1185. doi: 10.1038/s41590-019-0449-3. Epub 2019 Aug 12. Nat Immunol. 2019. PMID: 31406377 Free PMC article.
Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis.
Huang X, Ferris ST, Kim S, Choudhary MNK, Belk JA, Fan C, Qi Y, Sudan R, Xia Y, Desai P, Chen J, Ly N, Shi Q, Bagadia P, Liu T, Guilliams M, Egawa T, Colonna M, Diamond MS, Murphy TL, Satpathy AT, Wang T, Murphy KM. Huang X, et al. Immunity. 2021 Jul 13;54(7):1417-1432.e7. doi: 10.1016/j.immuni.2021.04.015. Epub 2021 May 17. Immunity. 2021. PMID: 34004142 Free PMC article.
Ablation of cDC2 development by triple mutations within the Zeb2 enhancer.
Liu TT, Kim S, Desai P, Kim DH, Huang X, Ferris ST, Wu R, Ou F, Egawa T, Van Dyken SJ, Diamond MS, Johnson PF, Kubo M, Murphy TL, Murphy KM. Liu TT, et al. Among authors: huang x. Nature. 2022 Jul;607(7917):142-148. doi: 10.1038/s41586-022-04866-z. Epub 2022 Jun 22. Nature. 2022. PMID: 35732734 Free PMC article.
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