Du Q - Search Results

1

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation.

Christie RJ, Tiberghien AC, Du Q, Bezabeh B, Fleming R, Shannon A, Mao S, Breen S, Zhang J, Zhong H, Harper J, Wu H, Howard PW, Gao C. Christie RJ, et al. Among authors: du q. Antibodies (Basel). 2017 Nov 28;6(4):20. doi: 10.3390/antib6040020. Antibodies (Basel). 2017. PMID: 31548535 Free PMC article.

2

Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer.

Bosco EE, Christie RJ, Carrasco R, Sabol D, Zha J, DaCosta K, Brown L, Kennedy M, Meekin J, Phipps S, Ayriss J, Du Q, Bezabeh B, Chowdhury P, Breen S, Chen C, Reed M, Hinrichs M, Zhong H, Xiao Z, Dixit R, Herbst R, Tice DA. Bosco EE, et al. Among authors: du q. Oncotarget. 2018 May 1;9(33):22960-22975. doi: 10.18632/oncotarget.25160. eCollection 2018 May 1. Oncotarget. 2018. PMID: 29796165 Free PMC article.

3

Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen.

Wang B, Yang C, Jin X, Du Q, Wu H, Dall'Acqua W, Mazor Y. Wang B, et al. Among authors: du q. MAbs. 2020 Jan-Dec;12(1):1690959. doi: 10.1080/19420862.2019.1690959. MAbs. 2020. PMID: 31829766 Free PMC article.

4

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways.

Rios-Doria J, Sabol D, Chesebrough J, Stewart D, Xu L, Tammali R, Cheng L, Du Q, Schifferli K, Rothstein R, Leow CC, Heidbrink-Thompson J, Jin X, Gao C, Friedman J, Wilkinson B, Damschroder M, Pierce AJ, Hollingsworth RE, Tice DA, Michelotti EF. Rios-Doria J, et al. Among authors: du q. Mol Cancer Ther. 2015 Jul;14(7):1637-49. doi: 10.1158/1535-7163.MCT-14-1040. Epub 2015 May 6. Mol Cancer Ther. 2015. PMID: 25948294

5

Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy.

Varkey R, Du Q, Karnell JL, Xiao X, Casey KA, Woods R, Rosenthal K, Wilson S, Dall'Acqua WF, Wu H, Herbst R, Ettinger R, Damschroder M. Varkey R, et al. Among authors: du q. PLoS One. 2019 Jan 25;14(1):e0211236. doi: 10.1371/journal.pone.0211236. eCollection 2019. PLoS One. 2019. PMID: 30682117 Free PMC article.

6

Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions.

Du Q, Damschroder M, Pabst TM, Hunter AK, Wang WK, Luo H. Du Q, et al. MAbs. 2019 May/Jun;11(4):789-802. doi: 10.1080/19420862.2019.1599634. Epub 2019 Apr 14. MAbs. 2019. PMID: 30913985 Free PMC article.

7

Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.

Cannon DA, Shan L, Du Q, Shirinian L, Rickert KW, Rosenthal KL, Korade M 3rd, van Vlerken-Ysla LE, Buchanan A, Vaughan TJ, Damschroder MM, Popovic B. Cannon DA, et al. Among authors: du q. PLoS Comput Biol. 2019 May 1;15(5):e1006980. doi: 10.1371/journal.pcbi.1006980. eCollection 2019 May. PLoS Comput Biol. 2019. PMID: 31042706 Free PMC article.

8

Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.

Hua L, Hilliard JJ, Shi Y, Tkaczyk C, Cheng LI, Yu X, Datta V, Ren S, Feng H, Zinsou R, Keller A, O'Day T, Du Q, Cheng L, Damschroder M, Robbie G, Suzich J, Stover CK, Sellman BR. Hua L, et al. Among authors: du q. Antimicrob Agents Chemother. 2014;58(2):1108-17. doi: 10.1128/AAC.02190-13. Epub 2013 Dec 2. Antimicrob Agents Chemother. 2014. PMID: 24295977 Free PMC article.

9

Characterization of IgG1 Fc Deamidation at Asparagine 325 and Its Impact on Antibody-dependent Cell-mediated Cytotoxicity and FcγRIIIa Binding.

Lu X, Machiesky LA, De Mel N, Du Q, Xu W, Washabaugh M, Jiang XR, Wang J. Lu X, et al. Among authors: du q. Sci Rep. 2020 Jan 15;10(1):383. doi: 10.1038/s41598-019-57184-2. Sci Rep. 2020. PMID: 31941950 Free PMC article.

10

Electrostatically Driven Protein-Protein Interactions: Quantitative Prediction of Second Osmotic Virial Coefficients to Aid Antibody Design.

Shahfar H, Du Q, Parupudi A, Shan L, Esfandiary R, Roberts CJ. Shahfar H, et al. Among authors: du q. J Phys Chem Lett. 2022 Feb 10;13(5):1366-1372. doi: 10.1021/acs.jpclett.1c03669. Epub 2022 Feb 3. J Phys Chem Lett. 2022. PMID: 35112863

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