Howard PW - Search Results

1

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation.

Christie RJ, Tiberghien AC, Du Q, Bezabeh B, Fleming R, Shannon A, Mao S, Breen S, Zhang J, Zhong H, Harper J, Wu H, Howard PW, Gao C. Christie RJ, et al. Among authors: howard pw. Antibodies (Basel). 2017 Nov 28;6(4):20. doi: 10.3390/antib6040020. Antibodies (Basel). 2017. PMID: 31548535 Free PMC article.

2

Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents.

Cooper N, Hagan DR, Tiberghien A, Ademefun T, Matthews CS, Howard PW, Thurston DE. Cooper N, et al. Among authors: howard pw. Chem Commun (Camb). 2002 Aug 21;(16):1764-5. doi: 10.1039/b205136b. Chem Commun (Camb). 2002. PMID: 12196988

3

Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).

Tiberghien AC, Hagan D, Howard PW, Thurston DE. Tiberghien AC, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5041-4. doi: 10.1016/j.bmcl.2004.08.002. Bioorg Med Chem Lett. 2004. PMID: 15380195

4

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.

Wells G, Martin CR, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE. Wells G, et al. Among authors: howard pw. J Med Chem. 2006 Sep 7;49(18):5442-61. doi: 10.1021/jm051199z. J Med Chem. 2006. PMID: 16942018

5

An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.

Tiberghien AC, Evans DA, Kiakos K, Martin CR, Hartley JA, Thurston DE, Howard PW. Tiberghien AC, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2073-7. doi: 10.1016/j.bmcl.2008.01.096. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18272367

6

Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.

Howard PW, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Cooper N, Fang M, Coffils MJ, Klee S, Hartley JA, Thurston DE. Howard PW, et al. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6463-6. doi: 10.1016/j.bmcl.2009.09.012. Epub 2009 Sep 9. Bioorg Med Chem Lett. 2009. PMID: 19811912

7

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity.

Hartley JA, Hamaguchi A, Coffils M, Martin CR, Suggitt M, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Hartley JM, Pepper C, Lin TT, Fegan C, Thurston DE, Howard PW. Hartley JA, et al. Among authors: howard pw. Cancer Res. 2010 Sep 1;70(17):6849-58. doi: 10.1158/0008-5472.CAN-10-0790. Epub 2010 Jul 26. Cancer Res. 2010. PMID: 20660714 Free PMC article.

8

A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.

Jeffrey SC, Burke PJ, Lyon RP, Meyer DW, Sussman D, Anderson M, Hunter JH, Leiske CI, Miyamoto JB, Nicholas ND, Okeley NM, Sanderson RJ, Stone IJ, Zeng W, Gregson SJ, Masterson L, Tiberghien AC, Howard PW, Thurston DE, Law CL, Senter PD. Jeffrey SC, et al. Among authors: howard pw. Bioconjug Chem. 2013 Jul 17;24(7):1256-63. doi: 10.1021/bc400217g. Epub 2013 Jun 28. Bioconjug Chem. 2013. PMID: 23808985

9

Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry.

VanBrunt MP, Shanebeck K, Caldwell Z, Johnson J, Thompson P, Martin T, Dong H, Li G, Xu H, D'Hooge F, Masterson L, Bariola P, Tiberghien A, Ezeadi E, Williams DG, Hartley JA, Howard PW, Grabstein KH, Bowen MA, Marelli M. VanBrunt MP, et al. Among authors: howard pw. Bioconjug Chem. 2015 Nov 18;26(11):2249-60. doi: 10.1021/acs.bioconjchem.5b00359. Epub 2015 Sep 11. Bioconjug Chem. 2015. PMID: 26332743

10

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.

Flynn MJ, Zammarchi F, Tyrer PC, Akarca AU, Janghra N, Britten CE, Havenith CE, Levy JN, Tiberghien A, Masterson LA, Barry C, D'Hooge F, Marafioti T, Parren PW, Williams DG, Howard PW, van Berkel PH, Hartley JA. Flynn MJ, et al. Among authors: howard pw. Mol Cancer Ther. 2016 Nov;15(11):2709-2721. doi: 10.1158/1535-7163.MCT-16-0233. Epub 2016 Aug 17. Mol Cancer Ther. 2016. PMID: 27535974

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