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Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy.
Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S. Kumar A, et al. Among authors: gangadhariah m. Free Radic Biol Med. 2019 Dec;145:284-299. doi: 10.1016/j.freeradbiomed.2019.09.031. Epub 2019 Sep 28. Free Radic Biol Med. 2019. PMID: 31574345 Free PMC article.
Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations.
Kant S, Davuluri G, Alchirazi KA, Welch N, Heit C, Kumar A, Gangadhariah M, Kim A, McMullen MR, Willard B, Luse DS, Nagy LE, Vasiliou V, Marini AM, Weiner ID, Dasarathy S. Kant S, et al. Among authors: gangadhariah m. J Biol Chem. 2019 May 3;294(18):7231-7244. doi: 10.1074/jbc.RA118.005411. Epub 2019 Mar 14. J Biol Chem. 2019. PMID: 30872403 Free PMC article.
Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease.
Singh SS, Kumar A, Welch N, Sekar J, Mishra S, Bellar A, Gangadhariah M, Attaway A, Al Khafaji H, Wu X, Pathak V, Agrawal V, McMullen MR, Hornberger TA, Nagy LE, Davuluri G, Dasarathy S. Singh SS, et al. Among authors: gangadhariah m. Cell Physiol Biochem. 2021 Feb 6;55(1):91-116. doi: 10.33594/000000327. Cell Physiol Biochem. 2021. PMID: 33543862 Free PMC article.
Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia.
Davuluri G, Giusto M, Chandel R, Welch N, Alsabbagh K, Kant S, Kumar A, Kim A, Gangadhariah M, Ghosh PK, Tran U, Krajcik DM, Vasu K, DiDonato AJ, DiDonato JA, Willard B, Monga SP, Wang Y, Fox PL, Stark GR, Wessely O, Esser KA, Dasarathy S. Davuluri G, et al. Among authors: gangadhariah m. Mol Cell Biol. 2019 Jul 29;39(16):e00451-18. doi: 10.1128/MCB.00451-18. Print 2019 Aug 15. Mol Cell Biol. 2019. PMID: 31138664 Free PMC article.
Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease.
Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S. Davuluri G, et al. Among authors: gangadhariah m. Hepatology. 2021 May;73(5):1892-1908. doi: 10.1002/hep.31524. Epub 2021 Apr 20. Hepatology. 2021. PMID: 32799332 Free PMC article.
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.
Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A. Sausville LN, et al. Among authors: gangadhariah mh. Cancer Res. 2018 Sep 1;78(17):4865-4877. doi: 10.1158/0008-5472.CAN-17-3977. Epub 2018 Jul 16. Cancer Res. 2018. PMID: 30012669 Free PMC article.
PPARα activation can help prevent and treat non-small cell lung cancer.
Skrypnyk N, Chen X, Hu W, Su Y, Mont S, Yang S, Gangadhariah M, Wei S, Falck JR, Jat JL, Zent R, Capdevila JH, Pozzi A. Skrypnyk N, et al. Among authors: gangadhariah m. Cancer Res. 2014 Jan 15;74(2):621-31. doi: 10.1158/0008-5472.CAN-13-1928. Epub 2013 Dec 3. Cancer Res. 2014. PMID: 24302581 Free PMC article.
15 results