Chen Q - Search Results

1

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity.

Niu L, Yang J, Yan W, Yu Y, Zheng Y, Ye H, Chen Q, Chen L. Niu L, et al. Among authors: chen l, chen q. J Biol Chem. 2019 Nov 29;294(48):18099-18108. doi: 10.1074/jbc.RA119.010732. Epub 2019 Oct 18. J Biol Chem. 2019. PMID: 31628188 Free PMC article.

2

BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression.

Jin S, Gao H, Mazzacurati L, Wang Y, Fan W, Chen Q, Yu W, Wang M, Zhu X, Zhang C, Zhan Q. Jin S, et al. Among authors: chen q. J Biol Chem. 2009 Aug 21;284(34):22970-7. doi: 10.1074/jbc.M109.009134. Epub 2009 Jun 9. J Biol Chem. 2009. PMID: 19509300 Free PMC article.

3

Protein production, crystallization and preliminary X-ray analysis of two isoforms of the Dscam1 Ig7 domain.

Li SA, Cheng L, Yu Y, Chen Q. Li SA, et al. Among authors: chen q. Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):330-2. doi: 10.1107/S2053230X15002897. Epub 2015 Feb 19. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 25760710 Free PMC article.

4

Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1.

Cheng L, Li SA, Wang JH, Yu Y, Chen Q. Cheng L, et al. Among authors: chen q. Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):775-8. doi: 10.1107/S2053230X15008201. Epub 2015 May 22. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26057811 Free PMC article.

5

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.

Wang Y, Zhang H, Gigant B, Yu Y, Wu Y, Chen X, Lai Q, Yang Z, Chen Q, Yang J. Wang Y, et al. Among authors: chen q, chen x. FEBS J. 2016 Jan;283(1):102-11. doi: 10.1111/febs.13555. Epub 2015 Nov 4. FEBS J. 2016. PMID: 26462166 Free article.

6

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule.

Yang J, Wang Y, Wang T, Jiang J, Botting CH, Liu H, Chen Q, Yang J, Naismith JH, Zhu X, Chen L. Yang J, et al. Among authors: chen l, chen q. Nat Commun. 2016 Jun 30;7:12103. doi: 10.1038/ncomms12103. Nat Commun. 2016. PMID: 27357539 Free PMC article.

7

Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition.

Li SA, Cheng L, Yu Y, Wang JH, Chen Q. Li SA, et al. Among authors: chen q. Sci Adv. 2016 May 27;2(5):e1501118. doi: 10.1126/sciadv.1501118. eCollection 2016 May. Sci Adv. 2016. PMID: 27386517 Free PMC article.

8

Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1. Corrigendum.

Cheng L, Li SA, Wang JH, Yu Y, Chen Q. Cheng L, et al. Among authors: chen q. Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):911. doi: 10.1107/S2053230X16017817. Epub 2016 Nov 30. Acta Crystallogr F Struct Biol Commun. 2016. PMID: 27917840 Free PMC article.

9

Mechanism of microtubule stabilization by taccalonolide AJ.

Wang Y, Yu Y, Li GB, Li SA, Wu C, Gigant B, Qin W, Chen H, Wu Y, Chen Q, Yang J. Wang Y, et al. Among authors: chen q, chen h. Nat Commun. 2017 Jun 6;8:15787. doi: 10.1038/ncomms15787. Nat Commun. 2017. PMID: 28585532 Free PMC article.

10

Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

Liu S, Ji S, Yu ZJ, Wang HL, Cheng X, Li WJ, Jing L, Yu Y, Chen Q, Yang LL, Li GB, Wu Y. Liu S, et al. Among authors: chen q. Chem Biol Drug Des. 2018 Jan;91(1):257-268. doi: 10.1111/cbdd.13077. Epub 2017 Aug 18. Chem Biol Drug Des. 2018. PMID: 28756638

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