Niu L - Search Results

1

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity.

Niu L, Yang J, Yan W, Yu Y, Zheng Y, Ye H, Chen Q, Chen L. Niu L, et al. J Biol Chem. 2019 Nov 29;294(48):18099-18108. doi: 10.1074/jbc.RA119.010732. Epub 2019 Oct 18. J Biol Chem. 2019. PMID: 31628188 Free PMC article.

2

Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design.

Niu L, Wang Y, Wang C, Wang Y, Jiang X, Ma L, Wu C, Yu Y, Chen Q. Niu L, et al. Biochem Biophys Res Commun. 2017 Nov 4;493(1):718-722. doi: 10.1016/j.bbrc.2017.08.125. Epub 2017 Aug 30. Biochem Biophys Res Commun. 2017. PMID: 28864414

3

Structural insights into the design of indole derivatives as tubulin polymerization inhibitors.

Li Y, Yang J, Niu L, Hu D, Li H, Chen L, Yu Y, Chen Q. Li Y, et al. Among authors: niu l. FEBS Lett. 2020 Jan;594(1):199-204. doi: 10.1002/1873-3468.13566. Epub 2019 Aug 16. FEBS Lett. 2020. PMID: 31369682 Free article.

4

The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation.

Yang J, Yan W, Li Y, Niu L, Ye H, Chen L. Yang J, et al. Among authors: niu l. Mol Pharmacol. 2019 Dec;96(6):711-719. doi: 10.1124/mol.119.117812. Epub 2019 Oct 4. Mol Pharmacol. 2019. PMID: 31585985

5

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect.

Yang J, Yu Y, Li Y, Yan W, Ye H, Niu L, Tang M, Wang Z, Yang Z, Pei H, Wei H, Zhao M, Wen J, Yang L, Ouyang L, Wei Y, Chen Q, Li W, Chen L. Yang J, et al. Among authors: niu l. Sci Adv. 2021 May 19;7(21):eabg4168. doi: 10.1126/sciadv.abg4168. Print 2021 May. Sci Adv. 2021. PMID: 34138737 Free PMC article.

6

Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2^V617F-induced myeloproliferative neoplasms.

Hu M, Yang T, Yang L, Niu L, Zhu J, Zhao A, Shi M, Yuan X, Tang M, Yang J, Pei H, Yang Z, Chen Q, Ye H, Niu T, Chen L. Hu M, et al. Among authors: niu t, niu l. Blood Cancer J. 2022 Mar 7;12(3):37. doi: 10.1038/s41408-022-00628-2. Blood Cancer J. 2022. PMID: 35256594 Free PMC article.

7

Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.

Yang J, Li Y, Qiu Q, Wang R, Yan W, Yu Y, Niu L, Pei H, Wei H, Ouyang L, Ye H, Xu D, Wei Y, Chen Q, Chen L. Yang J, et al. Among authors: niu l. J Med Chem. 2022 Jul 14;65(13):9159-9173. doi: 10.1021/acs.jmedchem.2c00379. Epub 2022 Jun 28. J Med Chem. 2022. PMID: 35762925

8

Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2^V617F-induced myeloproliferative neoplasms.

Hu M, Yang T, Yang L, Niu L, Zhu J, Zhao A, Shi M, Yuan X, Tang M, Yang J, Pei H, Yang Z, Chen Q, Ye H, Niu T, Chen L. Hu M, et al. Among authors: niu t, niu l. Blood Cancer J. 2024 Jun 26;14(1):104. doi: 10.1038/s41408-024-01058-y. Blood Cancer J. 2024. PMID: 38926354 Free PMC article. No abstract available.

9

Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.

Huang L, Li H, Li L, Niu L, Seupel R, Wu C, Cheng W, Chen C, Ding B, Brennan PE, Yang S. Huang L, et al. Among authors: niu l. J Med Chem. 2019 May 9;62(9):4526-4542. doi: 10.1021/acs.jmedchem.9b00096. Epub 2019 Apr 30. J Med Chem. 2019. PMID: 30998845

10

From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism.

Lyu M, Zhou J, Zhou Y, Chong W, Xu W, Lai H, Niu L, Hai Y, Yao X, Gong S, Wang Q, Chen Y, Wang Y, Chen L, Zengwanggema, Zeng J, Wang C, Ying B. Lyu M, et al. Among authors: niu l. Signal Transduct Target Ther. 2023 Feb 24;8(1):82. doi: 10.1038/s41392-023-01346-2. Signal Transduct Target Ther. 2023. PMID: 36828823 Free PMC article.

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