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Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding.
Boehm M, Tian X, Mao Y, Ichimura K, Dufva MJ, Ali K, Dannewitz Prosseda S, Shi Y, Kuramoto K, Reddy S, Kheyfets VO, Metzger RJ, Spiekerkoetter E. Boehm M, et al. Among authors: metzger rj. Cardiovasc Res. 2020 Aug 1;116(10):1700-1709. doi: 10.1093/cvr/cvz310. Cardiovasc Res. 2020. PMID: 31738411 Free PMC article.
FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension.
Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, Huebner K, Metzger RJ, Khatri P, Spiekerkoetter E. Dannewitz Prosseda S, et al. Among authors: metzger rj. Am J Respir Crit Care Med. 2019 Jan 1;199(1):83-98. doi: 10.1164/rccm.201712-2553OC. Am J Respir Crit Care Med. 2019. PMID: 30107138 Free PMC article.
A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions.
Steffes LC, Froistad AA, Andruska A, Boehm M, McGlynn M, Zhang F, Zhang W, Hou D, Tian X, Miquerol L, Nadeau K, Metzger RJ, Spiekerkoetter E, Kumar ME. Steffes LC, et al. Among authors: metzger rj. Circulation. 2020 Oct 20;142(16):1545-1561. doi: 10.1161/CIRCULATIONAHA.120.045750. Epub 2020 Aug 14. Circulation. 2020. PMID: 32794408 Free PMC article.
Improving Right Ventricular Function by Increasing BMP Signaling with FK506.
Boehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter E. Boehm M, et al. Among authors: metzger rj. Am J Respir Cell Mol Biol. 2021 Sep;65(3):272-287. doi: 10.1165/rcmb.2020-0528OC. Am J Respir Cell Mol Biol. 2021. PMID: 33938785 Free PMC article.
3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension.
Ichimura K, Boehm M, Andruska AM, Zhang F, Schimmel K, Bonham S, Kabiri A, Kheyfets VO, Ichimura S, Reddy S, Mao Y, Zhang T, Wang GX, Santana EJ, Tian X, Essafri I, Vinh R, Tian W, Nicolls MR, Yajima S, Shudo Y, MacArthur JW, Woo YJ, Metzger RJ, Spiekerkoetter E. Ichimura K, et al. Among authors: metzger rj. Circ Res. 2024 Jun 21;135(1):60-75. doi: 10.1161/CIRCRESAHA.123.323546. Epub 2024 May 21. Circ Res. 2024. PMID: 38770652
Cell types of origin of the cell-free transcriptome.
Vorperian SK, Moufarrej MN; Tabula Sapiens Consortium; Quake SR. Vorperian SK, et al. Nat Biotechnol. 2022 Jun;40(6):855-861. doi: 10.1038/s41587-021-01188-9. Epub 2022 Feb 7. Nat Biotechnol. 2022. PMID: 35132263 Free PMC article.
KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress.
Moonen JR, Chappell J, Shi M, Shinohara T, Li D, Mumbach MR, Zhang F, Nair RV, Nasser J, Mai DH, Taylor S, Wang L, Metzger RJ, Chang HY, Engreitz JM, Snyder MP, Rabinovitch M. Moonen JR, et al. Among authors: metzger rj. Nat Commun. 2022 Aug 23;13(1):4941. doi: 10.1038/s41467-022-32566-9. Nat Commun. 2022. PMID: 35999210 Free PMC article.
Capillary cell-type specialization in the alveolus.
Gillich A, Zhang F, Farmer CG, Travaglini KJ, Tan SY, Gu M, Zhou B, Feinstein JA, Krasnow MA, Metzger RJ. Gillich A, et al. Among authors: metzger rj. Nature. 2020 Oct;586(7831):785-789. doi: 10.1038/s41586-020-2822-7. Epub 2020 Oct 14. Nature. 2020. PMID: 33057196 Free PMC article.
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.
Tabula Sapiens Consortium*; Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Culver RN, Cvijović I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kong W, Kumar ME, Kuo AH, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG,… See abstract for full author list ➔ Tabula Sapiens Consortium*, et al. Among authors: metzger rj. Science. 2022 May 13;376(6594):eabl4896. doi: 10.1126/science.abl4896. Epub 2022 May 13. Science. 2022. PMID: 35549404 Free PMC article.
31 results