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Mcl-1 is essential for germinal center formation and B cell memory.
Vikstrom I, Carotta S, Lüthje K, Peperzak V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM. Vikstrom I, et al. Among authors: peperzak v. Science. 2010 Nov 19;330(6007):1095-9. doi: 10.1126/science.1191793. Epub 2010 Oct 7. Science. 2010. PMID: 20929728 Free PMC article.
Mcl-1 is essential for the survival of plasma cells.
Peperzak V, Vikström I, Walker J, Glaser SP, LePage M, Coquery CM, Erickson LD, Fairfax K, Mackay F, Strasser A, Nutt SL, Tarlinton DM. Peperzak V, et al. Nat Immunol. 2013 Mar;14(3):290-7. doi: 10.1038/ni.2527. Epub 2013 Feb 3. Nat Immunol. 2013. PMID: 23377201 Free PMC article.
MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.
Vikström IB, Slomp A, Carrington EM, Moesbergen LM, Chang C, Kelly GL, Glaser SP, Jansen JH, Leusen JH, Strasser A, Huang DC, Lew AM, Peperzak V, Tarlinton DM. Vikström IB, et al. Among authors: peperzak v. Cell Death Dis. 2016 Aug 25;7(8):e2345. doi: 10.1038/cddis.2016.237. Cell Death Dis. 2016. PMID: 27560714 Free PMC article.
38 results