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In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth-a clinically relevant distinction.
Moore DA, Sereno M, Das M, Baena Acevedo JD, Sinnadurai S, Smith C, McSweeney A, Su X, Officer L, Jones C, Dudek K, Guttery D, Taniere P, Spriggs RV, Le Quesne J. Moore DA, et al. Among authors: officer l. Mod Pathol. 2019 Jul;32(8):1095-1105. doi: 10.1038/s41379-019-0257-1. Epub 2019 Apr 1. Mod Pathol. 2019. PMID: 30932019 Free article.
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma.
AbdulJabbar K, Raza SEA, Rosenthal R, Jamal-Hanjani M, Veeriah S, Akarca A, Lund T, Moore DA, Salgado R, Al Bakir M, Zapata L, Hiley CT, Officer L, Sereno M, Smith CR, Loi S, Hackshaw A, Marafioti T, Quezada SA, McGranahan N, Le Quesne J; TRACERx Consortium; Swanton C, Yuan Y. AbdulJabbar K, et al. Among authors: officer l. Nat Med. 2020 Jul;26(7):1054-1062. doi: 10.1038/s41591-020-0900-x. Epub 2020 May 27. Nat Med. 2020. PMID: 32461698 Free PMC article.
The pathogenesis of mesothelioma is driven by a dysregulated translatome.
Grosso S, Marini A, Gyuraszova K, Voorde JV, Sfakianos A, Garland GD, Tenor AR, Mordue R, Chernova T, Morone N, Sereno M, Smith CP, Officer L, Farahmand P, Rooney C, Sumpton D, Das M, Teodósio A, Ficken C, Martin MG, Spriggs RV, Sun XM, Bushell M, Sansom OJ, Murphy D, MacFarlane M, Le Quesne JPC, Willis AE. Grosso S, et al. Among authors: officer l. Nat Commun. 2021 Aug 13;12(1):4920. doi: 10.1038/s41467-021-25173-7. Nat Commun. 2021. PMID: 34389715 Free PMC article.
Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis.
Ntala C, Salji M, Salmond J, Officer L, Teodosio AV, Blomme A, McGhee EJ, Powley I, Ahmad I, Kruithof-de Julio M, Thalmann G, Roberts E, Goodyear CS, Jamaspishvili T, Berman DM, Carlin LM, Le Quesne J, Leung HY. Ntala C, et al. Among authors: officer l. Eur Urol Open Sci. 2021 May 25;29:19-29. doi: 10.1016/j.euros.2021.05.001. eCollection 2021 Jul. Eur Urol Open Sci. 2021. PMID: 34337530 Free PMC article.
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Ghaddar N, Wang S, Woodvine B, Krishnamoorthy J, van Hoef V, Darini C, Kazimierczak U, Ah-Son N, Popper H, Johnson M, Officer L, Teodósio A, Broggini M, Mann KK, Hatzoglou M, Topisirovic I, Larsson O, Le Quesne J, Koromilas AE. Ghaddar N, et al. Among authors: officer l. Nat Commun. 2021 Jul 30;12(1):4651. doi: 10.1038/s41467-021-24661-0. Nat Commun. 2021. PMID: 34330898 Free PMC article.
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.
Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JD, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ. Knight JRP, et al. Among authors: officer l. Cancer Discov. 2021 May;11(5):1228-1247. doi: 10.1158/2159-8290.CD-20-0652. Epub 2020 Dec 16. Cancer Discov. 2021. PMID: 33328217 Free PMC article.
ALSUntangled #75: Portable neuromodulation stimulator therapy.
Officer L, Armon C, Barkhaus P, Beauchamp M, Benatar M, Bertorini T, Bowser R, Bromberg M, Brown A, Carbunar OM, Carter GT, Crayle J, Denson K, Feldman E, Fullam T, Heiman-Patterson T, Jackson C, Jhooty S, Levinson D, Li X, Linares A, Mallon E, Mascias Cadavid J, Mcdermott C, Mushannen T, Ostrow L, Patel R, Pattee G, Ratner D, Sun Y, Sladky J, Wicks P, Bedlack R. Officer L, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2024 Aug;25(5-6):648-652. doi: 10.1080/21678421.2024.2346825. Epub 2024 Apr 26. Amyotroph Lateral Scler Frontotemporal Degener. 2024. PMID: 38666601 Review.
14 results