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Galactosialidosis: preclinical enzyme replacement therapy in a mouse model of the disease, a proof of concept.
Cadaoas J, Hu H, Boyle G, Gomero E, Mosca R, Jayashankar K, Machado M, Cullen S, Guzman B, van de Vlekkert D, Annunziata I, Vellard M, Kakkis E, Koppaka V, d'Azzo A. Cadaoas J, et al. Among authors: boyle g. Mol Ther Methods Clin Dev. 2020 Nov 20;20:191-203. doi: 10.1016/j.omtm.2020.11.012. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33426146 Free PMC article.
Correction: SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.
Brown JL, Hart DW, Boyle GE, Brown TG, LaCroix M, Baraibar AM, Pelzel R, Kim M, Sherman MA, Boes S, Sung M, Cole T, Lee MK, Araque A, Lesné SE. Brown JL, et al. Among authors: boyle ge. Acta Neuropathol Commun. 2024 Jun 11;12(1):92. doi: 10.1186/s40478-024-01789-w. Acta Neuropathol Commun. 2024. PMID: 38863027 Free PMC article. No abstract available.
Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade.
Cullen JK, Yap PY, Ferguson B, Bruce ZC, Koyama M, Handoko H, Hendrawan K, Simmons JL, Brooks KM, Johns J, Wilson ES, de Souza MMA, Broit N, Stewart P, Shelley D, McMahon T, Ogbourne SM, Nguyen TH, Lim YC, Pagani A, Appendino G, Gordon VA, Reddell PW, Boyle GM, Parsons PG. Cullen JK, et al. Among authors: boyle gm. J Immunother Cancer. 2024 Apr 24;12(4):e006602. doi: 10.1136/jitc-2022-006602. J Immunother Cancer. 2024. PMID: 38658031 Free PMC article.
First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug.
Pieren M, Abáigar Gutiérrez-Solana A, Antonijoan Arbós RM, Boyle GW, Davila M, Davy M, Gitzinger M, Husband L, Martínez-Martínez MS, Mazarro DO, Pefani E, Penman SL, Remuiñán MJ, Vlasakakis G, Zeitlinger M, Dale GE. Pieren M, et al. Among authors: boyle gw. J Antimicrob Chemother. 2024 Jun 3;79(6):1353-1361. doi: 10.1093/jac/dkae107. J Antimicrob Chemother. 2024. PMID: 38656557 Free PMC article. Clinical Trial.
384 results