Siegwart DJ - Search Results

1

Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles.

Zhou K, Johnson LT, Xiong H, Barrios S, Minnig JT, Yan Y, Abram B, Yu X, Siegwart DJ. Zhou K, et al. Among authors: siegwart dj. Mol Pharm. 2020 May 4;17(5):1575-1585. doi: 10.1021/acs.molpharmaceut.9b01288. Epub 2020 Apr 23. Mol Pharm. 2020. PMID: 32267707

2

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery.

Hao J, Kos P, Zhou K, Miller JB, Xue L, Yan Y, Xiong H, Elkassih S, Siegwart DJ. Hao J, et al. Among authors: siegwart dj. J Am Chem Soc. 2015 Jul 29;137(29):9206-9. doi: 10.1021/jacs.5b03429. Epub 2015 Jul 17. J Am Chem Soc. 2015. PMID: 26166403

3

Precise let-7 expression levels balance organ regeneration against tumor suppression.

Wu L, Nguyen LH, Zhou K, de Soysa TY, Li L, Miller JB, Tian J, Locker J, Zhang S, Shinoda G, Seligson MT, Zeitels LR, Acharya A, Wang SC, Mendell JT, He X, Nishino J, Morrison SJ, Siegwart DJ, Daley GQ, Shyh-Chang N, Zhu H. Wu L, et al. Among authors: siegwart dj. Elife. 2015 Oct 7;4:e09431. doi: 10.7554/eLife.09431. Elife. 2015. PMID: 26445246 Free PMC article.

4

One-pot Synthesis of Functional Poly(amino ester sulfide)s and Utility in Delivering pDNA and siRNA.

Yan Y, Xue L, Miller JB, Zhou K, Kos P, Elkassih S, Liu L, Nagai A, Xiong H, Siegwart DJ. Yan Y, et al. Among authors: siegwart dj. Polymer (Guildf). 2015 Aug 18;72:271-280. doi: 10.1016/j.polymer.2015.02.020. Polymer (Guildf). 2015. PMID: 26726270 Free PMC article.

5

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model.

Zhou K, Nguyen LH, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ. Zhou K, et al. Among authors: siegwart dj. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):520-5. doi: 10.1073/pnas.1520756113. Epub 2016 Jan 4. Proc Natl Acad Sci U S A. 2016. PMID: 26729861 Free PMC article.

6

Activatable Water-Soluble Probes Enhance Tumor Imaging by Responding to Dysregulated pH and Exhibiting High Tumor-to-Liver Fluorescence Emission Contrast.

Xiong H, Kos P, Yan Y, Zhou K, Miller JB, Elkassih S, Siegwart DJ. Xiong H, et al. Among authors: siegwart dj. Bioconjug Chem. 2016 Jul 20;27(7):1737-44. doi: 10.1021/acs.bioconjchem.6b00242. Epub 2016 Jun 20. Bioconjug Chem. 2016. PMID: 27285307

7

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells.

Yan Y, Liu L, Xiong H, Miller JB, Zhou K, Kos P, Huffman KE, Elkassih S, Norman JW, Carstens R, Kim J, Minna JD, Siegwart DJ. Yan Y, et al. Among authors: siegwart dj. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5702-10. doi: 10.1073/pnas.1606886113. Epub 2016 Sep 12. Proc Natl Acad Sci U S A. 2016. PMID: 27621434 Free PMC article.

8

Intercalation-mediated nucleic acid nanoparticles for siRNA delivery.

Zhou K, Kos P, Yan Y, Xiong H, Min YL, Kinghorn KA, Minnig JT, Miller JB, Siegwart DJ. Zhou K, et al. Among authors: siegwart dj. Chem Commun (Camb). 2016 Oct 6;52(82):12155-12158. doi: 10.1039/c6cc06024b. Chem Commun (Camb). 2016. PMID: 27711272

9

Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors.

Yan Y, Zhou K, Xiong H, Miller JB, Motea EA, Boothman DA, Liu L, Siegwart DJ. Yan Y, et al. Among authors: siegwart dj. Biomaterials. 2017 Feb;118:84-93. doi: 10.1016/j.biomaterials.2016.12.001. Epub 2016 Dec 2. Biomaterials. 2017. PMID: 27974266 Free PMC article.

10

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA.

Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ. Miller JB, et al. Among authors: siegwart dj. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1059-1063. doi: 10.1002/anie.201610209. Epub 2016 Dec 16. Angew Chem Int Ed Engl. 2017. PMID: 27981708 Free PMC article.

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