Yu X - Search Results

1

Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles.

Zhou K, Johnson LT, Xiong H, Barrios S, Minnig JT, Yan Y, Abram B, Yu X, Siegwart DJ. Zhou K, et al. Among authors: yu x. Mol Pharm. 2020 May 4;17(5):1575-1585. doi: 10.1021/acs.molpharmaceut.9b01288. Epub 2020 Apr 23. Mol Pharm. 2020. PMID: 32267707

2

Lipid-Modified Aminoglycosides for mRNA Delivery to the Liver.

Yu X, Liu S, Cheng Q, Wei T, Lee S, Zhang D, Siegwart DJ. Yu X, et al. Adv Healthc Mater. 2020 Apr;9(7):e1901487. doi: 10.1002/adhm.201901487. Epub 2020 Feb 28. Adv Healthc Mater. 2020. PMID: 32108440 Free PMC article.

3

A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo.

Lee SM, Cheng Q, Yu X, Liu S, Johnson LT, Siegwart DJ. Lee SM, et al. Among authors: yu x. Angew Chem Int Ed Engl. 2021 Mar 8;60(11):5848-5853. doi: 10.1002/anie.202013927. Epub 2021 Feb 1. Angew Chem Int Ed Engl. 2021. PMID: 33305471 Free PMC article.

4

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing.

Liu S, Cheng Q, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ. Liu S, et al. Among authors: yu x. Nat Mater. 2021 May;20(5):701-710. doi: 10.1038/s41563-020-00886-0. Epub 2021 Feb 4. Nat Mater. 2021. PMID: 33542471 Free PMC article.

5

Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration.

Yu X, Liu S, Cheng Q, Lee SM, Wei T, Zhang D, Farbiak L, Johnson LT, Wang X, Siegwart DJ. Yu X, et al. Pharmaceutics. 2021 Nov 12;13(11):1914. doi: 10.3390/pharmaceutics13111914. Pharmaceutics. 2021. PMID: 34834329 Free PMC article.

6

Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes.

Liu S, Wang X, Yu X, Cheng Q, Johnson LT, Chatterjee S, Zhang D, Lee SM, Sun Y, Lin TC, Liu JL, Siegwart DJ. Liu S, et al. Among authors: yu x. J Am Chem Soc. 2021 Dec 22;143(50):21321-21330. doi: 10.1021/jacs.1c09822. Epub 2021 Dec 8. J Am Chem Soc. 2021. PMID: 34878786 Free PMC article.

7

In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.

Jia Y, Li L, Lin YH, Gopal P, Shen S, Zhou K, Yu X, Sharma T, Zhang Y, Siegwart DJ, Ready JM, Zhu H. Jia Y, et al. Among authors: yu x. Cell Stem Cell. 2022 Mar 3;29(3):372-385.e8. doi: 10.1016/j.stem.2022.01.001. Epub 2022 Jan 31. Cell Stem Cell. 2022. PMID: 35090595 Free PMC article.

8

Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy.

Zhang D, Wang G, Yu X, Wei T, Farbiak L, Johnson LT, Taylor AM, Xu J, Hong Y, Zhu H, Siegwart DJ. Zhang D, et al. Among authors: yu x. Nat Nanotechnol. 2022 Jul;17(7):777-787. doi: 10.1038/s41565-022-01122-3. Epub 2022 May 12. Nat Nanotechnol. 2022. PMID: 35551240 Free PMC article.

9

Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery.

Wang X, Liu S, Sun Y, Yu X, Lee SM, Cheng Q, Wei T, Gong J, Robinson J, Zhang D, Lian X, Basak P, Siegwart DJ. Wang X, et al. Among authors: yu x. Nat Protoc. 2023 Jan;18(1):265-291. doi: 10.1038/s41596-022-00755-x. Epub 2022 Oct 31. Nat Protoc. 2023. PMID: 36316378 Free PMC article. Review.

10

A convergent approach toward fidaxomicin: Syntheses of the fully glycosylated northern and southern fragments.

Hollibaugh R, Yu X, De Brabander JK. Hollibaugh R, et al. Among authors: yu x. Tetrahedron. 2020 Dec 4;79(4):131673. doi: 10.1016/j.tet.2020.131673. Epub 2020 Oct 12. Tetrahedron. 2020. PMID: 33191957 Free PMC article.

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