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Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death.
Otano I, Alvarez M, Minute L, Ochoa MC, Migueliz I, Molina C, Azpilikueta A, de Andrea CE, Etxeberria I, Sanmamed MF, Teijeira Á, Berraondo P, Melero I. Otano I, et al. Theranostics. 2020 Mar 15;10(10):4481-4489. doi: 10.7150/thno.41646. eCollection 2020. Theranostics. 2020. PMID: 32292509 Free PMC article.
Treatment of chronic viral hepatitis in woodchucks by prolonged intrahepatic expression of interleukin-12.
Crettaz J, Otano I, Ochoa-Callejero L, Benito A, Paneda A, Aurrekoetxea I, Berraondo P, Rodríguez-Madoz JR, Astudillo A, Kreppel F, Kochanek S, Ruiz J, Menne S, Prieto J, Gonzalez-Aseguinolaza G. Crettaz J, et al. Among authors: otano i. J Virol. 2009 Mar;83(6):2663-74. doi: 10.1128/JVI.02384-08. Epub 2008 Dec 30. J Virol. 2009. PMID: 19116251 Free PMC article.
Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.
Fernandez-Poma SM, Salas-Benito D, Lozano T, Casares N, Riezu-Boj JI, Mancheño U, Elizalde E, Alignani D, Zubeldia N, Otano I, Conde E, Sarobe P, Lasarte JJ, Hervas-Stubbs S. Fernandez-Poma SM, et al. Among authors: otano i. Cancer Res. 2017 Jul 1;77(13):3672-3684. doi: 10.1158/0008-5472.CAN-17-0236. Epub 2017 May 18. Cancer Res. 2017. PMID: 28522749
CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs.
Zapata JM, Perez-Chacon G, Carr-Baena P, Martinez-Forero I, Azpilikueta A, Otano I, Melero I. Zapata JM, et al. Among authors: otano i. Front Immunol. 2018 Nov 15;9:2618. doi: 10.3389/fimmu.2018.02618. eCollection 2018. Front Immunol. 2018. PMID: 30524423 Free PMC article. Review.
Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy.
Perez-Ruiz E, Minute L, Otano I, Alvarez M, Ochoa MC, Belsue V, de Andrea C, Rodriguez-Ruiz ME, Perez-Gracia JL, Marquez-Rodas I, Llacer C, Alvarez M, de Luque V, Molina C, Teijeira A, Berraondo P, Melero I. Perez-Ruiz E, et al. Among authors: otano i. Nature. 2019 May;569(7756):428-432. doi: 10.1038/s41586-019-1162-y. Epub 2019 May 1. Nature. 2019. PMID: 31043740 Free article.
Twists and turns to translating 4-1BB cancer immunotherapy.
Sanmamed MF, Etxeberría I, Otano I, Melero I. Sanmamed MF, et al. Among authors: otano i. Sci Transl Med. 2019 Jun 12;11(496):eaax4738. doi: 10.1126/scitranslmed.aax4738. Sci Transl Med. 2019. PMID: 31189719 Review.
Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells.
Etxeberria I, Bolaños E, Quetglas JI, Gros A, Villanueva A, Palomero J, Sánchez-Paulete AR, Piulats JM, Matias-Guiu X, Olivera I, Ochoa MC, Labiano S, Garasa S, Rodriguez I, Vidal A, Mancheño U, Hervás-Stubbs S, Azpilikueta A, Otano I, Aznar MA, Sanmamed MF, Inogés S, Berraondo P, Teijeira Á, Melero I. Etxeberria I, et al. Among authors: otano i. Cancer Cell. 2019 Dec 9;36(6):613-629.e7. doi: 10.1016/j.ccell.2019.10.006. Epub 2019 Nov 21. Cancer Cell. 2019. PMID: 31761658 Free article.
31 results