Young JD - Search Results

1

Mechanism-based identification of plasma metabolites associated with liver toxicity.

Pannala VR, Estes SK, Rahim M, Trenary I, O'Brien TP, Shiota C, Printz RL, Reifman J, Oyama T, Shiota M, Young JD, Wallqvist A. Pannala VR, et al. Among authors: young jd. Toxicology. 2020 Aug;441:152493. doi: 10.1016/j.tox.2020.152493. Epub 2020 May 30. Toxicology. 2020. PMID: 32479839

2

Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.

Egnatchik RA, Leamy AK, Noguchi Y, Shiota M, Young JD. Egnatchik RA, et al. Among authors: young jd. Metabolism. 2014 Feb;63(2):283-95. doi: 10.1016/j.metabol.2013.10.009. Epub 2013 Oct 24. Metabolism. 2014. PMID: 24286856 Free PMC article.

3

Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells.

Leamy AK, Egnatchik RA, Shiota M, Ivanova PT, Myers DS, Brown HA, Young JD. Leamy AK, et al. Among authors: young jd. J Lipid Res. 2014 Jul;55(7):1478-88. doi: 10.1194/jlr.M050237. Epub 2014 May 23. J Lipid Res. 2014. PMID: 24859739 Free PMC article.

4

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload.

Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD. Egnatchik RA, et al. Among authors: young jd. Mol Metab. 2014 May 22;3(5):544-53. doi: 10.1016/j.molmet.2014.05.004. eCollection 2014 Aug. Mol Metab. 2014. PMID: 25061559 Free PMC article.

5

Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets.

Wall ML, Pound LD, Trenary I, O'Brien RM, Young JD. Wall ML, et al. Among authors: young jd. Diabetes. 2015 Jun;64(6):2129-37. doi: 10.2337/db14-0745. Epub 2014 Dec 31. Diabetes. 2015. PMID: 25552595 Free PMC article.

6

LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells.

Whang YM, Park SI, Trenary IA, Egnatchik RA, Fessel JP, Kaufman JM, Carbone DP, Young JD. Whang YM, et al. Among authors: young jd. Oncogene. 2016 Feb 18;35(7):856-66. doi: 10.1038/onc.2015.140. Epub 2015 Jun 29. Oncogene. 2016. PMID: 26119936 Free PMC article.

7

Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes.

Leamy AK, Hasenour CM, Egnatchik RA, Trenary IA, Yao CH, Patti GJ, Shiota M, Young JD. Leamy AK, et al. Among authors: young jd. Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1005-1014. doi: 10.1016/j.bbalip.2016.05.013. Epub 2016 May 29. Biochim Biophys Acta. 2016. PMID: 27249207 Free PMC article.

8

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer.

Hutton JE, Wang X, Zimmerman LJ, Slebos RJ, Trenary IA, Young JD, Li M, Liebler DC. Hutton JE, et al. Among authors: young jd. Mol Cell Proteomics. 2016 Sep;15(9):2924-38. doi: 10.1074/mcp.M116.058925. Epub 2016 Jun 23. Mol Cell Proteomics. 2016. PMID: 27340238 Free PMC article.

9

The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.

Rahman SMJ, Ji X, Zimmerman LJ, Li M, Harris BK, Hoeksema MD, Trenary IA, Zou Y, Qian J, Slebos RJ, Beane J, Spira A, Shyr Y, Eisenberg R, Liebler DC, Young JD, Massion PP. Rahman SMJ, et al. Among authors: young jd. JCI Insight. 2016 Nov 17;1(19):e88814. doi: 10.1172/jci.insight.88814. JCI Insight. 2016. PMID: 27882349 Free PMC article.

10

The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism.

Fensterheim BA, Young JD, Luan L, Kleinbard RR, Stothers CL, Patil NK, McAtee-Pereira AG, Guo Y, Trenary I, Hernandez A, Fults JB, Williams DL, Sherwood ER, Bohannon JK. Fensterheim BA, et al. Among authors: young jd. J Immunol. 2018 Jun 1;200(11):3777-3789. doi: 10.4049/jimmunol.1800085. Epub 2018 Apr 23. J Immunol. 2018. PMID: 29686054 Free PMC article.

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