Sinz M - Search Results

1

Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.

Gu X, Wang L, Gan J, Fancher RM, Tian Y, Hong Y, Lai Y, Sinz M, Shen H. Gu X, et al. Among authors: sinz m. Drug Metab Dispos. 2020 Aug;48(8):724-734. doi: 10.1124/dmd.120.090670. Epub 2020 Jun 1. Drug Metab Dispos. 2020. PMID: 32482623

2

Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A.

Panfen E, Chen W, Zhang Y, Sinz M, Marathe P, Gan J, Shen H. Panfen E, et al. Among authors: sinz m. Drug Metab Dispos. 2019 Nov;47(11):1352-1360. doi: 10.1124/dmd.119.087197. Epub 2019 Aug 19. Drug Metab Dispos. 2019. PMID: 31427432

3

Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.

Zhang Y, Chen C, Chen SJ, Chen XQ, Shuster DJ, Puszczalo PD, Fancher RM, Yang Z, Sinz M, Shen H. Zhang Y, et al. Among authors: sinz m. J Pharmacol Exp Ther. 2020 Oct;375(1):139-151. doi: 10.1124/jpet.120.000139. Epub 2020 Jul 27. J Pharmacol Exp Ther. 2020. PMID: 32719071

4

Detection of Weak Organic Anion-Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans.

Zhang Y, Holenarsipur VK, Kandoussi H, Zeng J, Mariappan TT, Sinz M, Shen H. Zhang Y, et al. Among authors: sinz m. Drug Metab Dispos. 2020 Oct;48(10):841-848. doi: 10.1124/dmd.120.000076. Epub 2020 Jul 28. Drug Metab Dispos. 2020. PMID: 32723847

5

Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative.

Luo G, Lin J, Fiske WD, Dai R, Yang TJ, Kim S, Sinz M, LeCluyse E, Solon E, Brennan JM, Benedek IH, Jolley S, Gilbert D, Wang L, Lee FW, Gan LS. Luo G, et al. Among authors: sinz m. Drug Metab Dispos. 2003 Sep;31(9):1170-5. doi: 10.1124/dmd.31.9.1170. Drug Metab Dispos. 2003. PMID: 12920173

6

Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.

Shen H, Yao M, Sinz M, Marathe P, Rodrigues AD, Zhu M. Shen H, et al. Among authors: sinz m. Mol Pharm. 2019 Sep 3;16(9):4065-4076. doi: 10.1021/acs.molpharmaceut.9b00472. Epub 2019 Aug 7. Mol Pharm. 2019. PMID: 31335150

7

Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate.

Zhang Y, Panfen E, Fancher M, Sinz M, Marathe P, Shen H. Zhang Y, et al. Among authors: sinz m. Mol Pharm. 2019 Jun 3;16(6):2342-2353. doi: 10.1021/acs.molpharmaceut.8b01226. Epub 2019 May 13. Mol Pharm. 2019. PMID: 31039308

8

Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.

Chatterjee S, Mukherjee S, Sankara Sivaprasad LVJ, Naik T, Gautam SS, Murali BV, Hadambar AA, Gunti GR, Kuchibhotla V, Deyati A, Basavanthappa S, Ramarao M, Mariappan TT, Zinker BA, Zhang Y, Sinz M, Shen H. Chatterjee S, et al. Among authors: sinz m. J Pharmacol Exp Ther. 2021 Jan;376(1):29-39. doi: 10.1124/jpet.120.000291. Epub 2020 Oct 30. J Pharmacol Exp Ther. 2021. PMID: 33127749

9

Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.

Selvakumar S, Bhutani P, Ghosh K, Krishnamurthy P, Kallipatti S, Selvam S, Ramarao M, Mandlekar S, Sinz MW, Rodrigues AD, Subramanian M. Selvakumar S, et al. Among authors: sinz mw. Drug Metab Dispos. 2014 Mar;42(3):369-76. doi: 10.1124/dmd.113.055491. Epub 2013 Dec 13. Drug Metab Dispos. 2014. PMID: 24335510

10

Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.

Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, Mosure KW, Vuppugalla R, Grace JE Jr, Simmermacher J, Dulac HA, Pizzano J, Sinz M. Kim S, et al. Among authors: sinz m. Drug Metab Dispos. 2010 Jan;38(1):16-24. doi: 10.1124/dmd.109.029637. Drug Metab Dispos. 2010. PMID: 19833845

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