Wang L - Search Results

1

Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.

Gu X, Wang L, Gan J, Fancher RM, Tian Y, Hong Y, Lai Y, Sinz M, Shen H. Gu X, et al. Among authors: wang l. Drug Metab Dispos. 2020 Aug;48(8):724-734. doi: 10.1124/dmd.120.090670. Epub 2020 Jun 1. Drug Metab Dispos. 2020. PMID: 32482623

2

Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative.

Luo G, Lin J, Fiske WD, Dai R, Yang TJ, Kim S, Sinz M, LeCluyse E, Solon E, Brennan JM, Benedek IH, Jolley S, Gilbert D, Wang L, Lee FW, Gan LS. Luo G, et al. Among authors: wang l. Drug Metab Dispos. 2003 Sep;31(9):1170-5. doi: 10.1124/dmd.31.9.1170. Drug Metab Dispos. 2003. PMID: 12920173

3

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG. Zhang D, et al. Among authors: wang l. Drug Metab Dispos. 2013 Apr;41(4):827-35. doi: 10.1124/dmd.112.050260. Epub 2013 Feb 4. Drug Metab Dispos. 2013. PMID: 23382458

4

Tissue distribution and tumor uptake of folate receptor-targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration.

Shen H, Wang L, Chen W, Menard K, Hong Y, Tian Y, Bonacorsi SJ, Humphreys WG, Lee FY, Gan J. Shen H, et al. Among authors: wang l. Acta Pharm Sin B. 2016 Sep;6(5):460-467. doi: 10.1016/j.apsb.2016.07.009. Epub 2016 Aug 11. Acta Pharm Sin B. 2016. PMID: 27709015 Free PMC article.

5

Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

Chen W, Wang L, Van Berkel GJ, Kertesz V, Gan J. Chen W, et al. Among authors: wang l. J Chromatogr A. 2016 Mar 25;1439:137-143. doi: 10.1016/j.chroma.2015.10.093. Epub 2015 Nov 3. J Chromatogr A. 2016. PMID: 26589943

6

Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys.

Christopher LJ, Cui D, Li W, Barros A Jr, Arora VK, Zhang H, Wang L, Zhang D, Manning JA, He K, Fletcher AM, Ogan M, Lago M, Bonacorsi SJ, Humphreys WG, Iyer RA. Christopher LJ, et al. Among authors: wang l. Drug Metab Dispos. 2008 Jul;36(7):1341-56. doi: 10.1124/dmd.107.018234. Epub 2008 Apr 17. Drug Metab Dispos. 2008. PMID: 18420785

7

Development of a carbon-14 labeling approach to support disposition studies with a pegylated biologic.

Wang H, Wang L, Cao K, Emanuel SL, Morin P, Lin Z, Shen G, Hosbach J, Zhang D, Bonacorsi S, Rodrigues AD, Yang Z. Wang H, et al. Among authors: wang l. Drug Metab Dispos. 2012 Sep;40(9):1677-85. doi: 10.1124/dmd.112.044792. Epub 2012 May 24. Drug Metab Dispos. 2012. PMID: 22627466

8

Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.

Cheng Y, Wang L, Iacono L, Zhang D, Chen W, Gong J, Humphreys WG, Gan J. Cheng Y, et al. Among authors: wang l. Br J Clin Pharmacol. 2018 Jan;84(1):130-141. doi: 10.1111/bcp.13421. Epub 2017 Oct 4. Br J Clin Pharmacol. 2018. PMID: 28850715 Free PMC article. Clinical Trial.

9

Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.

Zhang D, He K, Raghavan N, Wang L, Mitroka J, Maxwell BD, Knabb RM, Frost C, Schuster A, Hao F, Gu Z, Humphreys WG, Grossman SJ. Zhang D, et al. Among authors: wang l. Drug Metab Dispos. 2009 Aug;37(8):1738-48. doi: 10.1124/dmd.108.025981. Epub 2009 May 6. Drug Metab Dispos. 2009. PMID: 19420130 Clinical Trial.

10

Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats.

Zhang D, Frost CE, He K, Rodrigues AD, Wang X, Wang L, Goosen TC, Humphreys WG. Zhang D, et al. Among authors: wang x, wang l. Drug Metab Dispos. 2013 Apr;41(4):906-15. doi: 10.1124/dmd.112.050575. Epub 2013 Feb 5. Drug Metab Dispos. 2013. PMID: 23386703

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