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The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators.
Gorshkov K, Chen CZ, Bostwick R, Rasmussen L, Xu M, Pradhan M, Tran BN, Zhu W, Shamim K, Huang W, Hu X, Shen M, Klumpp-Thomas C, Itkin Z, Shinn P, Simeonov A, Michael S, Hall MD, Lo DC, Zheng W. Gorshkov K, et al. Among authors: zhu w. bioRxiv [Preprint]. 2020 May 28:2020.05.16.091520. doi: 10.1101/2020.05.16.091520. bioRxiv. 2020. Update in: ACS Infect Dis. 2021 Jun 11;7(6):1389-1408. doi: 10.1021/acsinfecdis.0c00349. PMID: 32511355 Free PMC article. Updated. Preprint.
The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules.
Gorshkov K, Chen CZ, Bostwick R, Rasmussen L, Tran BN, Cheng YS, Xu M, Pradhan M, Henderson M, Zhu W, Oh E, Susumu K, Wolak M, Shamim K, Huang W, Hu X, Shen M, Klumpp-Thomas C, Itkin Z, Shinn P, Carlos de la Torre J, Simeonov A, Michael SG, Hall MD, Lo DC, Zheng W. Gorshkov K, et al. Among authors: zhu w. ACS Infect Dis. 2021 Jun 11;7(6):1389-1408. doi: 10.1021/acsinfecdis.0c00349. Epub 2020 Dec 21. ACS Infect Dis. 2021. PMID: 33346633 Free PMC article.
An OpenData portal to share COVID-19 drug repurposing data in real time.
Brimacombe KR, Zhao T, Eastman RT, Hu X, Wang K, Backus M, Baljinnyam B, Chen CZ, Chen L, Eicher T, Ferrer M, Fu Y, Gorshkov K, Guo H, Hanson QM, Itkin Z, Kales SC, Klumpp-Thomas C, Lee EM, Michael S, Mierzwa T, Patt A, Pradhan M, Renn A, Shinn P, Shrimp JH, Viraktamath A, Wilson KM, Xu M, Zakharov AV, Zhu W, Zheng W, Simeonov A, Mathé EA, Lo DC, Hall MD, Shen M. Brimacombe KR, et al. Among authors: zhu w. bioRxiv [Preprint]. 2020 Jun 5:2020.06.04.135046. doi: 10.1101/2020.06.04.135046. bioRxiv. 2020. PMID: 32511420 Free PMC article. Preprint.
Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles.
Chen CZ, Xu M, Pradhan M, Gorshkov K, Petersen J, Straus MR, Zhu W, Shinn P, Guo H, Shen M, Klumpp-Thomas C, Michael SG, Zimmerberg J, Zheng W, Whittaker GR. Chen CZ, et al. Among authors: zhu w. bioRxiv [Preprint]. 2020 Aug 18:2020.07.10.197988. doi: 10.1101/2020.07.10.197988. bioRxiv. 2020. Update in: ACS Pharmacol Transl Sci. 2020 Oct 19;3(6):1165-1175. doi: 10.1021/acsptsci.0c00112. PMID: 32839777 Free PMC article. Updated. Preprint.
Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles.
Chen CZ, Xu M, Pradhan M, Gorshkov K, Petersen JD, Straus MR, Zhu W, Shinn P, Guo H, Shen M, Klumpp-Thomas C, Michael SG, Zimmerberg J, Zheng W, Whittaker GR. Chen CZ, et al. Among authors: zhu w. ACS Pharmacol Transl Sci. 2020 Oct 19;3(6):1165-1175. doi: 10.1021/acsptsci.0c00112. eCollection 2020 Dec 11. ACS Pharmacol Transl Sci. 2020. PMID: 33330839 Free PMC article.
Biological activity-based modeling identifies antiviral leads against SARS-CoV-2.
Huang R, Xu M, Zhu H, Chen CZ, Zhu W, Lee EM, He S, Zhang L, Zhao J, Shamim K, Bougie D, Huang W, Xia M, Hall MD, Lo D, Simeonov A, Austin CP, Qiu X, Tang H, Zheng W. Huang R, et al. Among authors: zhu w, zhu h. Nat Biotechnol. 2021 Jun;39(6):747-753. doi: 10.1038/s41587-021-00839-1. Epub 2021 Feb 23. Nat Biotechnol. 2021. PMID: 33623157 Free PMC article.
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