Amaral MD - Search Results

1

Characterization of the mechanism of action of RDR01752, a novel corrector of F508del-CFTR.

Lopes-Pacheco M, Silva IAL, Turner MJ, Carlile GW, Sondo E, Thomas DY, Pedemonte N, Hanrahan JW, Amaral MD. Lopes-Pacheco M, et al. Among authors: amaral md. Biochem Pharmacol. 2020 Oct;180:114133. doi: 10.1016/j.bcp.2020.114133. Epub 2020 Jul 3. Biochem Pharmacol. 2020. PMID: 32628927

2

The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70.

Farinha CM, Nogueira P, Mendes F, Penque D, Amaral MD. Farinha CM, et al. Among authors: amaral md. Biochem J. 2002 Sep 15;366(Pt 3):797-806. doi: 10.1042/BJ20011717. Biochem J. 2002. PMID: 12069690 Free PMC article.

3

CFTR and chaperones: processing and degradation.

Amaral MD. Amaral MD. J Mol Neurosci. 2004;23(1-2):41-8. doi: 10.1385/JMN:23:1-2:041. J Mol Neurosci. 2004. PMID: 15126691 Review.

4

Quantitative methods for the analysis of CFTR transcripts/splicing variants.

Amaral MD, Clarke LA, Ramalho AS, Beck S, Broackes-Carter F, Rowntree R, Mouchel N, Williams SH, Harris A, Tzetis M, Steiner B, Sanz J, Gallati S, Nissim-Rafinifa M, Kerem B, Hefferon T, Cutting GR, Goina E, Pagani F. Amaral MD, et al. J Cyst Fibros. 2004 Aug;3 Suppl 2:17-23. doi: 10.1016/j.jcf.2004.05.047. J Cyst Fibros. 2004. PMID: 15463919 Free article. Review.

5

Antibodies for CFTR studies.

Mendes F, Farinha CM, Roxo-Rosa M, Fanen P, Edelman A, Dormer R, McPherson M, Davidson H, Puchelle E, De Jonge H, Heda GD, Gentzsch M, Lukacs G, Penque D, Amaral MD. Mendes F, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:69-72. doi: 10.1016/j.jcf.2004.05.016. J Cyst Fibros. 2004. PMID: 15463931 Free article. Review.

6

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.

Farinha CM, Amaral MD. Farinha CM, et al. Among authors: amaral md. Mol Cell Biol. 2005 Jun;25(12):5242-52. doi: 10.1128/MCB.25.12.5242-5252.2005. Mol Cell Biol. 2005. PMID: 15923638 Free PMC article.

7

Characterization of novel airway submucosal gland cell models for cystic fibrosis studies.

da Paula AC, Ramalho AS, Farinha CM, Cheung J, Maurisse R, Gruenert DC, Ousingsawat J, Kunzelmann K, Amaral MD. da Paula AC, et al. Among authors: amaral md. Cell Physiol Biochem. 2005;15(6):251-62. doi: 10.1159/000087235. Cell Physiol Biochem. 2005. PMID: 16037690 Free article.

8

Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies.

Mendes F, Wakefield J, Bachhuber T, Barroso M, Bebok Z, Penque D, Kunzelmann K, Amaral MD. Mendes F, et al. Among authors: amaral md. Cell Physiol Biochem. 2005;16(4-6):281-90. doi: 10.1159/000089857. Cell Physiol Biochem. 2005. PMID: 16301828 Free article.

9

Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis.

Amaral MD, Kunzelmann K. Amaral MD, et al. Trends Pharmacol Sci. 2007 Jul;28(7):334-41. doi: 10.1016/j.tips.2007.05.004. Epub 2007 Jun 18. Trends Pharmacol Sci. 2007. PMID: 17573123 Review.

10

Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation.

Pissarra LS, Farinha CM, Xu Z, Schmidt A, Thibodeau PH, Cai Z, Thomas PJ, Sheppard DN, Amaral MD. Pissarra LS, et al. Among authors: amaral md. Chem Biol. 2008 Jan;15(1):62-9. doi: 10.1016/j.chembiol.2007.11.012. Chem Biol. 2008. PMID: 18215773

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