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Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 + T cells.
Kusnadi A, Ramírez-Suástegui C, Fajardo V, Chee SJ, Meckiff BJ, Simon H, Pelosi E, Seumois G, Ay F, Vijayanand P, Ottensmeier CH. Kusnadi A, et al. Among authors: simon h. bioRxiv [Preprint]. 2020 Jul 10:2020.07.09.194027. doi: 10.1101/2020.07.09.194027. bioRxiv. 2020. Update in: Sci Immunol. 2021 Jan 21;6(55):eabe4782. doi: 10.1126/sciimmunol.abe4782. PMID: 32676602 Free PMC article. Updated. Preprint.
Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 + T cells.
Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P. Meckiff BJ, et al. Among authors: simon h. bioRxiv [Preprint]. 2020 Jun 13:2020.06.12.148916. doi: 10.1101/2020.06.12.148916. bioRxiv. 2020. Update in: Cell. 2020 Nov 25;183(5):1340-1353.e16. doi: 10.1016/j.cell.2020.10.001. PMID: 32587963 Free PMC article. Updated. Preprint.
Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T Cells.
Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P. Meckiff BJ, et al. Among authors: simon h. SSRN [Preprint]. 2020 Jul 7:3641939. doi: 10.2139/ssrn.3641939. SSRN. 2020. Update in: Cell. 2020 Nov 25;183(5):1340-1353.e16. doi: 10.1016/j.cell.2020.10.001. PMID: 32742242 Free PMC article. Updated. Preprint.
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19.
Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Eschweiler S, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P. Meckiff BJ, et al. Among authors: simon h. Cell. 2020 Nov 25;183(5):1340-1353.e16. doi: 10.1016/j.cell.2020.10.001. Epub 2020 Oct 5. Cell. 2020. PMID: 33096020 Free PMC article.
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type-dependent effects of disease-risk variants.
Schmiedel BJ, Gonzalez-Colin C, Fajardo V, Rocha J, Madrigal A, Ramírez-Suástegui C, Bhattacharyya S, Simon H, Greenbaum JA, Peters B, Seumois G, Ay F, Chandra V, Vijayanand P. Schmiedel BJ, et al. Among authors: simon h. Sci Immunol. 2022 Feb 25;7(68):eabm2508. doi: 10.1126/sciimmunol.abm2508. Epub 2022 Feb 25. Sci Immunol. 2022. PMID: 35213211 Free PMC article.
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.
Eschweiler S, Ramírez-Suástegui C, Li Y, King E, Chudley L, Thomas J, Wood O, von Witzleben A, Jeffrey D, McCann K, Simon H, Mondal M, Wang A, Dicker M, Lopez-Guadamillas E, Chou TF, Dobbs NA, Essame L, Acton G, Kelly F, Halbert G, Sacco JJ, Schache AG, Shaw R, McCaul JA, Paterson C, Davies JH, Brennan PA, Singh RP, Loadman PM, Wilson W, Hackshaw A, Seumois G, Okkenhaug K, Thomas GJ, Jones TM, Ay F, Friberg G, Kronenberg M, Vanhaesebroeck B, Vijayanand P, Ottensmeier CH. Eschweiler S, et al. Among authors: simon h. Nature. 2022 May;605(7911):741-746. doi: 10.1038/s41586-022-04685-2. Epub 2022 May 4. Nature. 2022. PMID: 35508656 Free PMC article. Clinical Trial.
JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells.
Eschweiler S, Wang A, Ramírez-Suástegui C, von Witzleben A, Li Y, Chee SJ, Simon H, Mondal M, Ellis M, Thomas GJ, Chandra V, Ottensmeier CH, Vijayanand P. Eschweiler S, et al. Among authors: simon h. Cell Rep. 2023 Feb 28;42(2):112040. doi: 10.1016/j.celrep.2023.112040. Epub 2023 Jan 25. Cell Rep. 2023. PMID: 36701231 Free PMC article.
Cytotoxic CD4+ tissue-resident memory T cells are associated with asthma severity.
Herrera-De La Mata S, Ramírez-Suástegui C, Mistry H, Castañeda-Castro FE, Kyyaly MA, Simon H, Liang S, Lau L, Barber C, Mondal M, Zhang H, Arshad SH, Kurukulaaratchy RJ, Vijayanand P, Seumois G. Herrera-De La Mata S, et al. Among authors: simon h. Med. 2023 Dec 8;4(12):875-897.e8. doi: 10.1016/j.medj.2023.09.003. Epub 2023 Oct 20. Med. 2023. PMID: 37865091
Transcriptomes and metabolism define mouse and human MAIT cell populations.
Chandra S, Ascui G, Riffelmacher T, Chawla A, Ramírez-Suástegui C, Castelan VC, Seumois G, Simon H, Murray MP, Seo GY, Premlal ALR, Schmiedel B, Verstichel G, Li Y, Lin CH, Greenbaum J, Lamberti J, Murthy R, Nigro J, Cheroutre H, Ottensmeier CH, Hedrick SM, Lu LF, Vijayanand P, Kronenberg M. Chandra S, et al. Among authors: simon h. Sci Immunol. 2023 Nov 10;8(89):eabn8531. doi: 10.1126/sciimmunol.abn8531. Epub 2023 Nov 10. Sci Immunol. 2023. PMID: 37948512 Free PMC article.
1,981 results