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Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y. Liu Z, et al. Among authors: sodhi a. Nat Commun. 2017 Sep 19;8(1):584. doi: 10.1038/s41467-017-00551-2. Nat Commun. 2017. PMID: 28928465 Free PMC article.
PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients.
Qin Y, Zhang J, Babapoor-Farrokhran S, Applewhite B, Deshpande M, Megarity H, Flores-Bellver M, Aparicio-Domingo S, Ma T, Rui Y, Tzeng SY, Green JJ, Canto-Soler MV, Montaner S, Sodhi A. Qin Y, et al. Among authors: sodhi a. Sci Adv. 2022 Mar 4;8(9):eabm1896. doi: 10.1126/sciadv.abm1896. Epub 2022 Mar 2. Sci Adv. 2022. PMID: 35235351 Free PMC article.
VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy.
Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, Solomon S, Lutty G, Semenza GL, Montaner S, Sodhi A. Rodrigues M, et al. Among authors: sodhi a. Diabetes. 2013 Nov;62(11):3863-73. doi: 10.2337/db13-0014. Epub 2013 Jul 24. Diabetes. 2013. PMID: 23884892 Free PMC article.
Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.
Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A. Xin X, et al. Among authors: sodhi a. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3425-34. doi: 10.1073/pnas.1217091110. Epub 2013 Aug 19. Proc Natl Acad Sci U S A. 2013. PMID: 23959876 Free PMC article.
Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy.
Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mos J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I. Hu J, et al. Among authors: sodhi a. Nature. 2017 Dec 14;552(7684):248-252. doi: 10.1038/nature25013. Epub 2017 Dec 6. Nature. 2017. PMID: 29211719 Free PMC article.
300 results