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Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists.
Marcoux D, Bertrand MB, Weigelt CA, Yip S, Galella M, Park H, Wu DR, Wang J, Yarde M, Cvijic ME, Li S, Hynes J Jr, Tino JA, Zhao Q, Dhar TGM. Marcoux D, et al. Among authors: dhar tgm. Bioorg Med Chem Lett. 2020 Oct 1;30(19):127466. doi: 10.1016/j.bmcl.2020.127466. Epub 2020 Aug 5. Bioorg Med Chem Lett. 2020. PMID: 32763309
Novel diamide-based inhibitors of IMPDH.
Gu HH, Iwanowicz EJ, Guo J, Watterson SH, Shen Z, Pitts WJ, Dhar TG, Fleener CA, Rouleau K, Sherbina NZ, Witmer M, Tredup J, Hollenbaugh D. Gu HH, et al. Bioorg Med Chem Lett. 2002 May 6;12(9):1323-6. doi: 10.1016/s0960-894x(02)00132-4. Bioorg Med Chem Lett. 2002. PMID: 11965381
Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
Pitts WJ, Guo J, Dhar TG, Shen Z, Gu HH, Watterson SH, Bednarz MS, Chen BC, Barrish JC, Bassolino D, Cheney D, Fleener CA, Rouleau KA, Hollenbaugh DL, Iwanowicz EJ. Pitts WJ, et al. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2137-40. doi: 10.1016/s0960-894x(02)00351-7. Bioorg Med Chem Lett. 2002. PMID: 12127522
Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.
Watterson SH, Liu C, Dhar TG, Gu HH, Pitts WJ, Barrish JC, Fleener CA, Rouleau K, Sherbina NZ, Hollenbaugh DL, Iwanowicz EJ. Watterson SH, et al. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2879-82. doi: 10.1016/s0960-894x(02)00601-7. Bioorg Med Chem Lett. 2002. PMID: 12270168
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ. Watterson SH, et al. Bioorg Med Chem Lett. 2003 Feb 10;13(3):543-6. doi: 10.1016/s0960-894x(02)00944-7. Bioorg Med Chem Lett. 2003. PMID: 12565968
60 results