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A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions.
Steffes LC, Froistad AA, Andruska A, Boehm M, McGlynn M, Zhang F, Zhang W, Hou D, Tian X, Miquerol L, Nadeau K, Metzger RJ, Spiekerkoetter E, Kumar ME. Steffes LC, et al. Among authors: spiekerkoetter e. Circulation. 2020 Oct 20;142(16):1545-1561. doi: 10.1161/CIRCULATIONAHA.120.045750. Epub 2020 Aug 14. Circulation. 2020. PMID: 32794408 Free PMC article.
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension.
Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M. Merklinger SL, et al. Among authors: spiekerkoetter e. Circ Res. 2005 Sep 16;97(6):596-604. doi: 10.1161/01.RES.0000182425.49768.8a. Epub 2005 Aug 18. Circ Res. 2005. PMID: 16109920
S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4.
Spiekerkoetter E, Guignabert C, de Jesus Perez V, Alastalo TP, Powers JM, Wang L, Lawrie A, Ambartsumian N, Schmidt AM, Berryman M, Ashley RH, Rabinovitch M. Spiekerkoetter E, et al. Circ Res. 2009 Sep 25;105(7):639-47, 13 p following 647. doi: 10.1161/CIRCRESAHA.109.205120. Epub 2009 Aug 27. Circ Res. 2009. PMID: 19713532 Free PMC article.
Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans.
de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M. de Jesus Perez VA, et al. Among authors: spiekerkoetter e. Circ Res. 2012 Dec 7;111(12):1551-64. doi: 10.1161/CIRCRESAHA.112.267849. Epub 2012 Sep 25. Circ Res. 2012. PMID: 23011394 Free PMC article.
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. Spiekerkoetter E, et al. J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15. J Clin Invest. 2013. PMID: 23867624 Free PMC article.
Current clinical management of pulmonary arterial hypertension.
Zamanian RT, Kudelko KT, Sung YK, Perez VJ, Liu J, Spiekerkoetter E. Zamanian RT, et al. Among authors: spiekerkoetter e. Circ Res. 2014 Jun 20;115(1):131-147. doi: 10.1161/CIRCRESAHA.115.303827. Circ Res. 2014. PMID: 24951763 Free PMC article. Review.
71 results