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A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions.
Steffes LC, Froistad AA, Andruska A, Boehm M, McGlynn M, Zhang F, Zhang W, Hou D, Tian X, Miquerol L, Nadeau K, Metzger RJ, Spiekerkoetter E, Kumar ME. Steffes LC, et al. Among authors: tian x. Circulation. 2020 Oct 20;142(16):1545-1561. doi: 10.1161/CIRCULATIONAHA.120.045750. Epub 2020 Aug 14. Circulation. 2020. PMID: 32794408 Free PMC article.
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. Spiekerkoetter E, et al. Among authors: tian x. J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15. J Clin Invest. 2013. PMID: 23867624 Free PMC article.
FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension.
Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, Huebner K, Metzger RJ, Khatri P, Spiekerkoetter E. Dannewitz Prosseda S, et al. Among authors: tian x. Am J Respir Crit Care Med. 2019 Jan 1;199(1):83-98. doi: 10.1164/rccm.201712-2553OC. Am J Respir Crit Care Med. 2019. PMID: 30107138 Free PMC article.
Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding.
Boehm M, Tian X, Mao Y, Ichimura K, Dufva MJ, Ali K, Dannewitz Prosseda S, Shi Y, Kuramoto K, Reddy S, Kheyfets VO, Metzger RJ, Spiekerkoetter E. Boehm M, et al. Among authors: tian x. Cardiovasc Res. 2020 Aug 1;116(10):1700-1709. doi: 10.1093/cvr/cvz310. Cardiovasc Res. 2020. PMID: 31738411 Free PMC article.
Improving Right Ventricular Function by Increasing BMP Signaling with FK506.
Boehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter E. Boehm M, et al. Among authors: tian x. Am J Respir Cell Mol Biol. 2021 Sep;65(3):272-287. doi: 10.1165/rcmb.2020-0528OC. Am J Respir Cell Mol Biol. 2021. PMID: 33938785 Free PMC article.
Shunt-type plexiform lesions identified in the Sugen5416/hypoxia rat model of pulmonary arterial hypertension using synchrotron-based phase-contrast micro-CT.
van der Have O, Westöö C, Ahrné F, Tian X, Ichimura K, Dreier T, Norvik C, Kumar ME, Spiekerkoetter E, Tran-Lundmark K. van der Have O, et al. Among authors: tian x. Eur Respir J. 2022 Jun 9;59(6):2102802. doi: 10.1183/13993003.02802-2021. Print 2022 Jun. Eur Respir J. 2022. PMID: 35332070 Free PMC article.
3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension.
Ichimura K, Boehm M, Andruska AM, Zhang F, Schimmel K, Bonham S, Kabiri A, Kheyfets VO, Ichimura S, Reddy S, Mao Y, Zhang T, Wang GX, Santana EJ, Tian X, Essafri I, Vinh R, Tian W, Nicolls MR, Yajima S, Shudo Y, MacArthur JW, Woo YJ, Metzger RJ, Spiekerkoetter E. Ichimura K, et al. Among authors: tian x, tian w. Circ Res. 2024 Jun 21;135(1):60-75. doi: 10.1161/CIRCRESAHA.123.323546. Epub 2024 May 21. Circ Res. 2024. PMID: 38770652
Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant.
Heydarian M, Oak P, Zhang X, Kamgari N, Kindt A, Koschlig M, Pritzke T, Gonzalez-Rodriguez E, Förster K, Morty RE, Häfner F, Hübener C, Flemmer AW, Yildirim AO, Sudheendra D, Tian X, Petrera A, Kirsten H, Ahnert P, Morrell N, Desai TJ, Sucre J, Spiekerkoetter E, Hilgendorff A. Heydarian M, et al. Among authors: tian x. Thorax. 2022 Dec;77(12):1176-1186. doi: 10.1136/thoraxjnl-2021-218083. Epub 2022 May 17. Thorax. 2022. PMID: 35580897 Free PMC article.
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