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Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Manevski N, Swart P, Balavenkatraman KK, Bertschi B, Camenisch G, Kretz O, Schiller H, Walles M, Ling B, Wettstein R, Schaefer DJ, Itin P, Ashton-Chess J, Pognan F, Wolf A, Litherland K. Manevski N, et al. Drug Metab Dispos. 2015 Jan;43(1):126-39. doi: 10.1124/dmd.114.060350. Epub 2014 Oct 22. Drug Metab Dispos. 2015. PMID: 25339109
Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Yilmaz Y, Umehara K, Williams G, Faller T, Schiller H, Walles M, Kraehenbuehl S, Camenisch G, Manevski N. Yilmaz Y, et al. Among authors: manevski n. Xenobiotica. 2018 Aug;48(8):793-803. doi: 10.1080/00498254.2017.1373311. Epub 2017 Sep 29. Xenobiotica. 2018. PMID: 28879796
Aldehyde oxidase activity in fresh human skin.
Manevski N, Balavenkatraman KK, Bertschi B, Swart P, Walles M, Camenisch G, Schiller H, Kretz O, Ling B, Wettstein R, Schaefer DJ, Pognan F, Wolf A, Litherland K. Manevski N, et al. Drug Metab Dispos. 2014 Dec;42(12):2049-57. doi: 10.1124/dmd.114.060368. Epub 2014 Sep 23. Drug Metab Dispos. 2014. PMID: 25249692
Qualification of impurities based on metabolite data.
Weidolf L, Andersson T, Bercu JP, Brink A, Glowienke S, Harvey J, Hayes MA, Jacques P, Lu C, Manevski N, Muster W, Nudelman R, Ogilvie R, Ottosson J, Teasdale A, Trela B. Weidolf L, et al. Among authors: manevski n. Regul Toxicol Pharmacol. 2020 Feb;110:104524. doi: 10.1016/j.yrtph.2019.104524. Epub 2019 Nov 14. Regul Toxicol Pharmacol. 2020. PMID: 31734179
24 results