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Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Kathiriya JJ, et al. Nat Cell Biol. 2022 Jan;24(1):10-23. doi: 10.1038/s41556-021-00809-4. Epub 2021 Dec 30. Nat Cell Biol. 2022. PMID: 34969962 Free PMC article.
TGF-β1 Signaling and Tissue Fibrosis.
Kim KK, Sheppard D, Chapman HA. Kim KK, et al. Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):a022293. doi: 10.1101/cshperspect.a022293. Cold Spring Harb Perspect Biol. 2018. PMID: 28432134 Free PMC article. Review.
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.
Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. Xi Y, et al. Among authors: chapman ha. Nat Cell Biol. 2017 Aug;19(8):904-914. doi: 10.1038/ncb3580. Epub 2017 Jul 24. Nat Cell Biol. 2017. PMID: 28737769 Free PMC article.
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.
Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O'Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB. Strunz M, et al. Among authors: chapman ha. Nat Commun. 2020 Jul 16;11(1):3559. doi: 10.1038/s41467-020-17358-3. Nat Commun. 2020. PMID: 32678092 Free PMC article.
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Wang C, et al. J Clin Invest. 2018 Oct 1;128(10):4343-4358. doi: 10.1172/JCI99435. Epub 2018 Jul 12. J Clin Invest. 2018. PMID: 29999500 Free PMC article.
VEGF Drives the Car toward Better Gas Exchange.
Kathiriya JJ, Chapman HA. Kathiriya JJ, et al. Dev Cell. 2020 Mar 9;52(5):546-547. doi: 10.1016/j.devcel.2020.02.009. Dev Cell. 2020. PMID: 32155436 Free PMC article.
1,030 results